ENSMUSG00000007682


Mus musculus

Features
Gene ID: ENSMUSG00000007682
  
Biological name :Dio2
  
Synonyms : Dio2 / Q9Z1Y9 / Type II iodothyronine deiodinase
  
Possible biological names infered from orthology : iodothyronine deiodinase 2 / Q92813
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D3
Gene start: 90724552
Gene end: 90738438
  
Corresponding Affymetrix probe sets: 10401841 (MoGene1.0st)   1418937_at (Mouse Genome 430 2.0 Array)   1418938_at (Mouse Genome 430 2.0 Array)   1426081_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081013
NCBI entrez gene - 13371     See in Manteia.
MGI - MGI:1338833
RefSeq - NM_010050
RefSeq Peptide - NP_034180
swissprot - Q9Z1Y9
Ensembl - ENSMUSG00000007682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dio2ENSDARG00000094857Danio rerio
 DIO2ENSGALG00000026005Gallus gallus
 DIO2ENSG00000211448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dio3 / Q91ZI8 / Thyroxine 5-deiodinase / P55073* / iodothyronine deiodinase 3*ENSMUSG0000007570734
Dio1 / type I iodothyronine deiodinase / P49895* / iodothyronine deiodinase 1*ENSMUSG0000003478529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042403 thyroid hormone metabolic process ISO
 biological_processGO:0042404 thyroid hormone catabolic process IMP
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070460 thyroid-stimulating hormone secretion TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Dio2tm1Acb/Dio2tm1Acb,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003971 abnormal thyroid-stimulating hormone level 
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Dio2tm1Acb/Dio2tm1Acb,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dio2tm1Acb/Dio2tm1Acb,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0005470 increased thyroxine level "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Dio2tm1Acb/Dio2tm1Acb,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dio2tm1Acb/Dio2tm1Acb,Tg(Cga-cre)3Sac/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007682 Dio2 / Q9Z1Y9 / Type II iodothyronine deiodinase / Q92813* / iodothyronine deiodinase 2*  / complex






 

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