ENSMUSG00000075707


Mus musculus

Features
Gene ID: ENSMUSG00000075707
  
Biological name :Dio3
  
Synonyms : Dio3 / Q91ZI8 / Thyroxine 5-deiodinase
  
Possible biological names infered from orthology : iodothyronine deiodinase 3 / P55073
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 110279068
Gene end: 110281097
  
Corresponding Affymetrix probe sets: 10398446 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000094864
Ensembl peptide - ENSMUSP00000133920
NCBI entrez gene - 107585     See in Manteia.
MGI - MGI:1306782
RefSeq - NM_172119
RefSeq Peptide - NP_742117
swissprot - K3W4Q2
swissprot - Q91ZI8
Ensembl - ENSMUSG00000075707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DIO3ENSG00000197406Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dio2 / Q9Z1Y9 / Type II iodothyronine deiodinase / Q92813* / iodothyronine deiodinase 2*ENSMUSG0000000768230
Dio1 / type I iodothyronine deiodinase / P49895* / iodothyronine deiodinase 1*ENSMUSG0000003478527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR027252  Iodothyronine deiodinase I/III
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042404 thyroid hormone catabolic process IMP
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0033798 thyroxine 5-deiodinase activity IDA


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dio3tm1Dmst/Dio3tm1Dmst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003965 abnormal pituitary hormone level "aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005119 decreased circulating thyroid-stimulating hormone level "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dio3tm1Dmst/Dio3tm1Dmst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005474 increased triiodothyronine level "greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dio3tm1Dmst/Dio3tm1Dmst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dio3tm1Dmst/Dio3tm1Dmst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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