ENSMUSG00000034785


Mus musculus

Features
Gene ID: ENSMUSG00000034785
  
Biological name :Dio1
  
Synonyms : Dio1 / type I iodothyronine deiodinase
  
Possible biological names infered from orthology : iodothyronine deiodinase 1 / P49895
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C7
Gene start: 107291465
Gene end: 107307169
  
Corresponding Affymetrix probe sets: 10514912 (MoGene1.0st)   1417991_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081007
Ensembl peptide - ENSMUSP00000121450
Ensembl peptide - ENSMUSP00000119199
Ensembl peptide - ENSMUSP00000118335
Ensembl peptide - ENSMUSP00000117751
Ensembl peptide - ENSMUSP00000114807
Ensembl peptide - ENSMUSP00000102359
NCBI entrez gene - 13370     See in Manteia.
MGI - MGI:94896
RefSeq - NM_007860
RefSeq Peptide - NP_031886
swissprot - D3YVM7
swissprot - D6RDQ6
swissprot - A0A0R4J110
swissprot - A0A0R4J1U2
swissprot - D6RCH6
swissprot - D3YX15
Ensembl - ENSMUSG00000034785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DIO1ENSG00000211452Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dio3 / Q91ZI8 / Thyroxine 5-deiodinase / P55073* / iodothyronine deiodinase 3*ENSMUSG0000007570732
Dio2 / Q9Z1Y9 / Type II iodothyronine deiodinase / Q92813* / iodothyronine deiodinase 2*ENSMUSG0000000768230


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR027252  Iodothyronine deiodinase I/III
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002876 abnormal thyroid physiology "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005470 increased thyroxine level "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005474 increased triiodothyronine level "greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H19tm1Jvs/H19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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