ENSG00000211452


Homo sapiens

Features
Gene ID: ENSG00000211452
  
Biological name :DIO1
  
Synonyms : DIO1 / iodothyronine deiodinase 1 / P49895
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p32.3
Gene start: 53891239
Gene end: 53911086
  
Corresponding Affymetrix probe sets: 206457_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432797
Ensembl peptide - ENSP00000433891
Ensembl peptide - ENSP00000483367
Ensembl peptide - ENSP00000481665
Ensembl peptide - ENSP00000479755
Ensembl peptide - ENSP00000436550
Ensembl peptide - ENSP00000435725
Ensembl peptide - ENSP00000435030
Ensembl peptide - ENSP00000434758
Ensembl peptide - ENSP00000434152
Ensembl peptide - ENSP00000323198
Ensembl peptide - ENSP00000354643
Ensembl peptide - ENSP00000373528
Ensembl peptide - ENSP00000431999
Ensembl peptide - ENSP00000432700
NCBI entrez gene - 1733     See in Manteia.
OMIM - 147892
RefSeq - NM_001039716
RefSeq - NM_001324316
RefSeq - NM_213593
RefSeq - NM_000792
RefSeq - NM_001039715
RefSeq Peptide - NP_001034805
RefSeq Peptide - NP_001311245
RefSeq Peptide - NP_998758
RefSeq Peptide - NP_000783
RefSeq Peptide - NP_001034804
swissprot - P49895
swissprot - E9PI35
swissprot - D3DQ42
swissprot - C6ZRC2
swissprot - A0A182DWI2
swissprot - A0A087X0G2
swissprot - A0A087WYB0
swissprot - A0A087WVX4
swissprot - E9PM07
Ensembl - ENSG00000211452
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Dio1ENSMUSG00000034785Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DIO2 / Q92813 / iodothyronine deiodinase 2ENSG0000021144833
DIO3 / P55073 / iodothyronine deiodinase 3ENSG0000019740631


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR027252  Iodothyronine deiodinase I/III
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006590 thyroid hormone generation TAS
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IEA
 molecular_functionGO:0008430 selenium binding TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000211452 DIO1 / P49895 / iodothyronine deiodinase 1  / complex






 

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contact: otassy@igbmc.fr