ENSG00000197406


Homo sapiens

Features
Gene ID: ENSG00000197406
  
Biological name :DIO3
  
Synonyms : DIO3 / iodothyronine deiodinase 3 / P55073
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.31
Gene start: 101561351
Gene end: 101563452
  
Corresponding Affymetrix probe sets: 207154_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427336
NCBI entrez gene - 1735     See in Manteia.
OMIM - 601038
RefSeq - NM_001362
RefSeq Peptide - NP_001353
swissprot - P55073
Ensembl - ENSG00000197406
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Dio3ENSMUSG00000075707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DIO2 / Q92813 / iodothyronine deiodinase 2ENSG0000021144830
DIO1 / P49895 / iodothyronine deiodinase 1ENSG0000021145226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR027252  Iodothyronine deiodinase I/III
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006590 thyroid hormone generation TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042404 thyroid hormone catabolic process IEA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0046549 retinal cone cell development IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity NAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0033798 thyroxine 5-deiodinase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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