ENSG00000211448


Homo sapiens

Features
Gene ID: ENSG00000211448
  
Biological name :DIO2
  
Synonyms : DIO2 / iodothyronine deiodinase 2 / Q92813
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q31.1
Gene start: 80197527
Gene end: 80387757
  
Corresponding Affymetrix probe sets: 203699_s_at (Human Genome U133 Plus 2.0 Array)   203700_s_at (Human Genome U133 Plus 2.0 Array)   210819_x_at (Human Genome U133 Plus 2.0 Array)   211215_x_at (Human Genome U133 Plus 2.0 Array)   231240_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451971
Ensembl peptide - ENSP00000450781
Ensembl peptide - ENSP00000450547
Ensembl peptide - ENSP00000411438
Ensembl peptide - ENSP00000405854
Ensembl peptide - ENSP00000451339
Ensembl peptide - ENSP00000451419
Ensembl peptide - ENSP00000450980
Ensembl peptide - ENSP00000451136
Ensembl peptide - ENSP00000451265
NCBI entrez gene - 1734     See in Manteia.
OMIM - 601413
RefSeq - NM_013989
RefSeq - NM_000793
RefSeq - NM_001007023
RefSeq - NM_001242502
RefSeq - NM_001242503
RefSeq - NM_001324462
RefSeq Peptide - NP_000784
RefSeq Peptide - NP_054644
RefSeq Peptide - NP_001311391
RefSeq Peptide - NP_001229432
RefSeq Peptide - NP_001229431
RefSeq Peptide - NP_001007024
swissprot - Q92813
swissprot - A0A0A0MTQ2
swissprot - G3V2A7
swissprot - G3V3A8
swissprot - H0YJ42
swissprot - H0YJQ8
swissprot - J3KQY5
Ensembl - ENSG00000211448
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dio2ENSDARG00000094857Danio rerio
 DIO2ENSGALG00000026005Gallus gallus
 Dio2ENSMUSG00000007682Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DIO3 / P55073 / iodothyronine deiodinase 3ENSG0000019740630
DIO1 / P49895 / iodothyronine deiodinase 1ENSG0000021145227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000643  Iodothyronine deiodinase
 IPR008261  Iodothyronine deiodinase, active site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001514 selenocysteine incorporation NAS
 biological_processGO:0006590 thyroid hormone generation TAS
 biological_processGO:0042403 thyroid hormone metabolic process IDA
 biological_processGO:0042404 thyroid hormone catabolic process IEA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004800 thyroxine 5"-deiodinase activity IEA
 molecular_functionGO:0008430 selenium binding TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Regulation of thyroid hormone activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000211448 DIO2 / Q92813 / iodothyronine deiodinase 2  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr