Manteia

ENSDARG00000045843

Danio rerio

Features

Gene ID:	ENSDARG00000045843

Biological name :	apex1

Synonyms :	apex1 / APEX nuclease (multifunctional DNA repair enzyme) 1

Possible biological names infered from orthology :	apurinic/apyrimidinic endodeoxyribonuclease 1 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695 / P28352

Species:	Danio rerio

Chr. number:	4
Strand:	1
Band:
Gene start:	5333988
Gene end:	5340530

Corresponding Affymetrix probe sets:	Dr.20170.2.A1_at (Zebrafish Array) NM_213421_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000138791 Ensembl peptide - ENSDARP00000067373 Ensembl peptide - ENSDARP00000110718 Ensembl peptide - ENSDARP00000125428 Ensembl peptide - ENSDARP00000125398 Ensembl peptide - ENSDARP00000125208 Ensembl peptide - ENSDARP00000156404 Ensembl peptide - ENSDARP00000125549 Ensembl peptide - ENSDARP00000125593 NCBI entrez gene - 406730 See in Manteia. RefSeq - NM_001328578 RefSeq - NM_001328580 RefSeq - NM_213421 RefSeq - NM_001328579 RefSeq Peptide - NP_001315509 RefSeq Peptide - NP_001315508 RefSeq Peptide - NP_001315507 RefSeq Peptide - NP_998586 swissprot - H0WEW8 swissprot - A0A0R4IWF9 swissprot - F1QTR9 swissprot - H0WED1 swissprot - H0WEZ7 swissprot - H0WFB7 swissprot - H0WFG1 ZFIN ID - ZDB-GENE-040426-2761 Ensembl - ENSDARG00000045843

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
apex2 / APEX nuclease (apurinic/apyrimidinic endonuclease) 2 / Q68G58* / Q9UBZ4* / DNA-(apurinic or apyrimidinic site) lyase 2 * / apurinic/apyrimidinic endodeoxyribonuclease 2*	ENSDARG00000008472	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR004808	AP endonuclease 1
IPR005135	Endonuclease/exonuclease/phosphatase
IPR020847	AP endonuclease 1, binding site
IPR020848	AP endonuclease 1, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA
molecular_function	GO:0004518	nuclease activity	IEA
molecular_function	GO:0004519	endonuclease activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA
molecular_function	GO:0140080	class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA

Pathways (from Reactome)

Pathway description

Displacement of DNA glycosylase by APEX1

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000008	brain	brain deformed , abnormal	Show
ZFA:0000054	pericardium	pericardium edematous , abnormal	Show
ZFA:0000107	eye	eye decreased size , abnormal	Show
ZFA:0000114	heart	heart deformed , abnormal	Show
ZFA:0001094	whole organism	whole organism lethal (sensu genetics) , abnormal	Show
ZFA:0009256	nucleate erythrocyte	nucleate erythrocyte decreased amount , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr