ENSDARG00000052377


Danio rerio

Features
Gene ID: ENSDARG00000052377
  
Biological name :psmd12
  
Synonyms : proteasome 26S subunit, non-ATPase 12 / psmd12
  
Possible biological names infered from orthology : O00232 / proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 / Q9D8W5
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 21525543
Gene end: 21534301
  
Corresponding Affymetrix probe sets: Dr.20347.1.S1_at (Zebrafish Array)   Dr.20347.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000106592
NCBI entrez gene - 321898     See in Manteia.
swissprot - Q8AW07
ZFIN ID - ZDB-GENE-030131-617
Ensembl - ENSDARG00000052377
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD12ENSGALG00000026225Gallus gallus
 O00232ENSG00000197170Homo sapiens
 Psmd12ENSMUSG00000020720Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR035297  26S Proteasome non-ATPase regulatory subunit 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IBA
 cellular_componentGO:0031595 nuclear proteasome complex IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased amount , abnormal
ceratobranchial cartilage increased angle to whole organism anterior-posterior axis, abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule shape , abnormal
pronephric proximal convoluted tubule decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr