ENSDARG00000058806


Danio rerio

Features
Gene ID: ENSDARG00000058806
  
Biological name :naxe
  
Synonyms : NAD(P)HX epimerase / naxe / Q6DHK1
  
Possible biological names infered from orthology : NAD(P)H-hydrate epimerase / Q8K4Z3 / Q8NCW5
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 7408235
Gene end: 7412647
  
Corresponding Affymetrix probe sets: Dr.18415.1.A1_at (Zebrafish Array)   NM_001002618_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000076185
NCBI entrez gene - 436891     See in Manteia.
RefSeq - NM_001002618
RefSeq Peptide - NP_001002618
swissprot - Q6DHK1
ZFIN ID - ZDB-GENE-040718-362
Ensembl - ENSDARG00000058806
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000046023Gallus gallus
 NAXEENSG00000163382Homo sapiens
 NaxeENSMUSG00000028070Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
yjefn3 / YjeF N-terminal domain containing 3 / A6XGL0* / F6W8I0*ENSDARG0000006169240


Protein motifs (from Interpro)
Interpro ID Name
 IPR004443  YjeF N-terminal domain
 IPR032976  YjeF N-terminal domain-containing protein, eukaryotes


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006734 NADH metabolic process IBA
 biological_processGO:0006739 NADP metabolic process IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052856 NADHX epimerase activity IBA
 molecular_functionGO:0052857 NADPHX epimerase activity IBA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart blood plasma fatty , abnormal
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 ZFA:0000123 liver liver color , abnormal
liver increased size , abnormal
liver fatty , abnormal
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 ZFA:0009111 hepatocyte hepatocyte apoptotic , abnormal
hepatocyte necrotic , abnormal
hepatocyte ballooning , abnormal
hepatocyte nucleus broken , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000058806 naxe / Q6DHK1 / NAD(P)HX epimerase / Q8K4Z3* / Q8NCW5* / NAD(P)H-hydrate epimerase *  / complex






 

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