ENSDARG00000061600


Danio rerio

Features
Gene ID: ENSDARG00000061600
  
Biological name :tmem2
  
Synonyms : A3KPQ7 / tmem2 / transmembrane protein 2
  
Possible biological names infered from orthology : Cell surface hyaluronidase / Q5FWI3 / Q9UHN6
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 25760112
Gene end: 25814650
  
Corresponding Affymetrix probe sets: Dr.3402.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000150629
Ensembl peptide - ENSDARP00000156626
Ensembl peptide - ENSDARP00000082444
Ensembl peptide - ENSDARP00000118976
NCBI entrez gene - 566851     See in Manteia.
RefSeq - NM_001099449
RefSeq Peptide - NP_001092919
swissprot - A3KPQ7
swissprot - G0ZDN6
ZFIN ID - ZDB-GENE-030131-2179
Ensembl - ENSDARG00000061600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015138Gallus gallus
 TMEM2ENSG00000135048Homo sapiens
 Tmem2ENSMUSG00000024754Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cemip / cell migration inducing protein, hyaluronan binding / Q8BI06* / Q8WUJ3* / cell migration inducing hyaluronan binding protein* / Cell migration-inducing and hyaluronan-binding protein *ENSDARG0000003988133
pkhd1l1 / polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 / Q80ZA4* / Q86WI1* / PKHD1 like 1* / Fibrocystin-L *ENSDARG0000009111619
si:ch211-244a23.1 / Q86WI1* / Q80ZA4* / PKHD1L1* / PKHD1 like 1* / Fibrocystin-L *ENSDARG0000004000419


Protein motifs (from Interpro)
Interpro ID Name
 IPR011050  Pectin lyase fold/virulence factor
 IPR012334  Pectin lyase fold
 IPR019316  G8 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003190 atrioventricular valve formation IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003318 cell migration to the midline involved in heart development IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016203 muscle attachment IMP
 biological_processGO:0030214 hyaluronan catabolic process IMP
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060415 muscle tissue morphogenesis IMP
 biological_processGO:0060974 cell migration involved in heart formation IMP
 biological_processGO:1900748 positive regulation of vascular endothelial growth factor signaling pathway IDA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IMP
 biological_processGO:1903670 regulation of sprouting angiogenesis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle non-contractile , abnormal
cardiac ventricle bifurcated , abnormal
cardiac ventricle physical object quality , abnormal
cardiac ventricle malformed , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta endothelial cell decreased distribution , abnormal
dorsal aorta endothelial cell decreased amount , abnormal
dorsal aorta hyaluronic acid increased amount , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle lacks all parts of type otolith , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
extension increased width , abnormal
Show

 ZFA:0000155 somite somite obtuse , abnormal
somite morphology , abnormal
somite U-shaped , abnormal
Show

 ZFA:0000360 heart tube heart tube mislocalised radially , abnormal
Show

 ZFA:0000471 atrium atrium bifurcated , abnormal
atrium physical object quality , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein endothelial cell decreased distribution , abnormal
posterior cardinal vein endothelial cell decreased amount , abnormal
posterior cardinal vein hyaluronic acid increased amount , abnormal
Show

 ZFA:0001057 intersegmental vein intersegmental vein decreased amount , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery decreased amount , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region increased accumulation blood , abnormal
Show

 ZFA:0001261 ventricular system ventricular system decreased volume , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel sprouting angiogenesis decreased occurrence , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel amount , ameliorated
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal distended , abnormal
atrioventricular canal physical object quality , abnormal
Show

 ZFA:0001319 myocardium myocardium split medially , abnormal
myocardium spatial pattern , abnormal
myocardium extracellular matrix spatial pattern , abnormal
myocardium extracellular matrix disorganized , abnormal
Show

 ZFA:0001320 endocardium endocardium split medially , abnormal
Show

 ZFA:0001374 atrial myocardium atrial myocardium cardiac muscle cell shape , abnormal
Show

 ZFA:0001615 ventricular endocardium ventricular endocardium physical object quality , abnormal
ventricular endocardium increased distance ventricular myocardium , abnormal
Show

 ZFA:0001655 pericardial cavity pericardial cavity edematous , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle muscle tendon junction spatial pattern , abnormal
skeletal muscle muscle tendon junction disorganized , abnormal
skeletal muscle muscle tendon junction decreased amount , abnormal
skeletal muscle dystroglycan complex disorganized , abnormal
skeletal muscle extracellular matrix disorganized , abnormal
skeletal muscle protein complex involved in cell-matrix adhesion disorganized , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell detached from trunk musculature , abnormal
skeletal muscle cell detached from trunk musculature muscle tendon junction, abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell detached from trunk musculature , abnormal
slow muscle cell detached from trunk musculature muscle tendon junction, abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell detached from trunk musculature , abnormal
fast muscle cell detached from trunk musculature muscle tendon junction, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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