ENSDARG00000062727


Danio rerio

Features
Gene ID: ENSDARG00000062727
  
Biological name :cep290
  
Synonyms : centrosomal protein 290 / cep290
  
Possible biological names infered from orthology : Centrosomal protein of 290 kDa / O15078 / Q6A078
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 17934426
Gene end: 18002937
  
Corresponding Affymetrix probe sets: Dr.4610.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000124972
Ensembl peptide - ENSDARP00000141028
NCBI entrez gene - 560588     See in Manteia.
RefSeq - NM_001168267
RefSeq - XM_009297906
RefSeq - XM_009297907
RefSeq Peptide - NP_001161739
swissprot - F8W5U5
ZFIN ID - ZDB-GENE-041111-243
Ensembl - ENSDARG00000062727
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CEP290ENSGALG00000011177Gallus gallus
 CEP290ENSG00000198707Homo sapiens
 Cep290ENSMUSG00000019971Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026201  Centrosomal protein of 290kDa
 IPR032321  Centrosomal protein of 290kDa, coiled-coil region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060271 cilium assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Neutrophil degranulation
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
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 ZFA:0000008 brain brain decreased mass , abnormal
brain infiltrative , abnormal
brain hydrocephalic , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary decreased thickness , abnormal
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 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000100 cerebellum cerebellum organization quality , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye malformed , abnormal
eye lacks all parts of type lens , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle composition , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer lacks all parts of type photoreceptor cell photoreceptor outer segment, abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
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 ZFA:0000163 renal system renal system cystic , abnormal
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 ZFA:0000217 inner ear inner ear deformed , abnormal
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 ZFA:0000529 kidney kidney edematous , abnormal
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 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
whole organism dead , abnormal
whole organism curved ventral , abnormal
whole organism anterior-posterior axis increased curvature , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region increased curvature , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer disorganized , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus cystic , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule cystic , abnormal
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 ZFA:0005565 tether cell tether cell decreased size , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell decreased amount , ameliorated
neuromast hair cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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