ENSDARG00000069014


Danio rerio

Features
Gene ID: ENSDARG00000069014
  
Biological name :nphp4
  
Synonyms : nephronophthisis 4 / nphp4
  
Possible biological names infered from orthology : Mus musculus nephronophthisis 4 (juvenile) homolog (human) (Nphp4), transcript variant 2, mRNA. / nephrocystin 4 / O75161 / P59240
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 21978057
Gene end: 22274509
  
Corresponding Affymetrix probe sets: Dr.15520.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000134132
Ensembl peptide - ENSDARP00000140723
Ensembl peptide - ENSDARP00000153757
Ensembl peptide - ENSDARP00000090835
Ensembl peptide - ENSDARP00000110305
Ensembl peptide - ENSDARP00000123247
swissprot - A0A0R4IIP2
swissprot - A0A0R4IXQ2
swissprot - B3DG24
swissprot - F1QSP6
swissprot - F6NUK4
ZFIN ID - ZDB-GENE-060503-715
Ensembl - ENSDARG00000069014
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000039646Gallus gallus
 ENSGALG00000000966Gallus gallus
 NPHP4ENSG00000131697Homo sapiens
 Nphp4ENSMUSG00000039577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR013783  Immunoglobulin-like fold
 IPR029775  Nephrocystin-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0003401 axis elongation IGI
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:0035844 cloaca development IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IMP
 biological_processGO:0071910 determination of liver left/right asymmetry IMP
 biological_processGO:0072114 pronephros morphogenesis IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0097730 non-motile cilium IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium decreased length , abnormal
Kupffers vesicle motile cilium decreased fluid flow , abnormal
Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cilium decreased length , abnormal
pronephric duct decreased length , abnormal
pronephric duct increased thickness , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros obstructed , abnormal
Show

 ZFA:0000330 cloacal chamber cloacal chamber deformed , abnormal
cloacal chamber cell increased amount , abnormal
cloacal chamber cell increased height , abnormal
cloacal chamber cilium decreased length , abnormal
cloacal chamber dilated , abnormal
cloacal chamber cystic , abnormal
cloacal chamber cilium absent , abnormal
cloacal chamber cilium decreased amount , abnormal
cloacal chamber cilium decreased mobility , abnormal
Show

 ZFA:0000529 kidney kidney cystic , abnormal
Show

 ZFA:0001094 whole organism whole organism curved , abnormal
whole organism increased curvature , abnormal
Show

 ZFA:0001115 trunk trunk increased curvature , abnormal
Show

 ZFA:0001288 renal glomerulus renal glomerulus dilated , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
Show

 ZFA:0001617 otolith otolith amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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