ENSDARG00000070674


Danio rerio

Features
Gene ID: ENSDARG00000070674
  
Biological name :psmd6
  
Synonyms : proteasome 26S subunit, non-ATPase 6 / psmd6
  
Possible biological names infered from orthology : 26S proteasome non-ATPase regulatory subunit 6 / Q15008 / Q99JI4
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 19502297
Gene end: 19511548
  
Corresponding Affymetrix probe sets: Dr.17448.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000094762
NCBI entrez gene - 393261     See in Manteia.
RefSeq - NM_200291
RefSeq Peptide - NP_956585
swissprot - F1QZA5
ZFIN ID - ZDB-GENE-040426-1038
Ensembl - ENSDARG00000070674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD6ENSGALG00000007315Gallus gallus
 PSMD6ENSG00000163636Homo sapiens
 Psmd6ENSMUSG00000021737Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gps1 / G protein pathway suppressor 1 / Q13098*ENSDARG0000004065022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR019585  26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
 IPR035268  26S Proteasome non-ATPase regulatory subunit 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0070306 lens fiber cell differentiation IMP
 cellular_componentGO:0005838 proteasome regulatory particle IBA
 molecular_functionGO:0030234 enzyme regulator activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens nucleus circular , abnormal
lens nucleus mislocalised anteriorly , abnormal
lens nucleus decreased amount , abnormal
lens malformed , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary hemorrhagic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr