ENSMUSG00000021737


Mus musculus

Features
Gene ID: ENSMUSG00000021737
  
Biological name :Psmd6
  
Synonyms : 26S proteasome non-ATPase regulatory subunit 6 / Psmd6 / Q99JI4
  
Possible biological names infered from orthology : proteasome 26S subunit, non-ATPase 6 / Q15008
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A1
Gene start: 14112174
Gene end: 14120984
  
Corresponding Affymetrix probe sets: 10417689 (MoGene1.0st)   1423696_a_at (Mouse Genome 430 2.0 Array)   1423697_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153591
Ensembl peptide - ENSMUSP00000022256
NCBI entrez gene - 66413     See in Manteia.
MGI - MGI:1913663
RefSeq - NM_025550
RefSeq Peptide - NP_079826
swissprot - A0A286YDW8
swissprot - Q99JI4
Ensembl - ENSMUSG00000021737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd6ENSDARG00000070674Danio rerio
 PSMD6ENSGALG00000007315Gallus gallus
 PSMD6ENSG00000163636Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gps1 / G protein pathway suppressor 1 / Q13098*ENSMUSG0000002515622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR019585  26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
 IPR035268  26S Proteasome non-ATPase regulatory subunit 6
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005838 proteasome regulatory particle IBA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030234 enzyme regulator activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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