ENSDARG00000070686


Danio rerio

Features
Gene ID: ENSDARG00000070686
  
Biological name :cdipt
  
Synonyms : cdipt / CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
  
Possible biological names infered from orthology : CDP-diacylglycerol--inositol 3-phosphatidyltransferase / O14735 / Q8VDP6
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 21125293
Gene end: 21137362
  
Corresponding Affymetrix probe sets: Dr.13550.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000094826
NCBI entrez gene - 404620     See in Manteia.
RefSeq - NM_207088
RefSeq Peptide - NP_996971
swissprot - Q6DRN8
ZFIN ID - ZDB-GENE-040426-2536
Ensembl - ENSDARG00000070686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDIPTENSG00000103502Homo sapiens
 CdiptENSMUSG00000030682Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000462  CDP-alcohol phosphatidyltransferase
 IPR014387  CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0044255 cellular lipid metabolic process IMP
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IMP
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 biological_processGO:0071788 endoplasmic reticulum tubular network maintenance IMP
 biological_processGO:0072576 liver morphogenesis IMP
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016780 phosphotransferase activity, for other substituted phosphate groups IEA


Pathways (from Reactome)
Pathway description
Synthesis of PI


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
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 ZFA:0000035 lens lens cell apoptotic , abnormal
lens cell poorly differentiated , abnormal
lens cell disorganized , abnormal
lens decreased size , abnormal
lens degenerate , abnormal
lens morphology , abnormal
lens position , abnormal
lens disorganized , abnormal
lens opaque , abnormal
lens quality , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000109 forebrain forebrain decreased width , abnormal
Show

 ZFA:0000112 gut gut quality , abnormal
gut hypoplastic , abnormal
Show

 ZFA:0000123 liver liver quality , abnormal
liver hypoplastic , abnormal
liver spheroid , abnormal
liver fatty , abnormal
liver increased pigmentation , abnormal
liver blood vessel morphology , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer eye photoreceptor cell apoptotic , abnormal
retinal photoreceptor layer lacks all parts of type retinal cone cell , abnormal
retinal photoreceptor layer lacks all parts of type retinal rod cell , abnormal
retinal photoreceptor layer lacks parts or has fewer parts of type retinal cone cell , abnormal
retinal photoreceptor layer has fewer parts of type retinal rod cell , abnormal
retinal photoreceptor layer aplastic , abnormal
retinal photoreceptor layer retinal cone cell disorganized , abnormal
retinal photoreceptor layer retinal rod cell disorganized , abnormal
retinal photoreceptor layer eye photoreceptor cell disorganized , abnormal
retinal photoreceptor layer eye photoreceptor cell immature , abnormal
Show

 ZFA:0000152 retina retina lacks all parts of type photoreceptor outer segment layer , abnormal
retina central region lacks all parts of type eye photoreceptor cell , abnormal
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 ZFA:0000737 cranium cranium increased width , abnormal
cranium shortened , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism buoyancy , abnormal
Show

 ZFA:0001114 head head swollen , abnormal
head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk swollen , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton increased thickness , abnormal
Show

 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch protruding , abnormal
Show

 ZFA:0001289 ciliary marginal zone ciliary marginal zone hyperplastic , abnormal
Show

 ZFA:0001323 mid intestine mid intestine goblet cell decreased amount , abnormal
Show

 ZFA:0001326 lens epithelium lens epithelium columnar/cuboidal epithelial cell shape , abnormal
lens epithelium columnar/cuboidal epithelial cell disorganized , abnormal
lens epithelium disorganized , abnormal
lens epithelium columnar/cuboidal epithelial cell morphology , abnormal
Show

 ZFA:0001338 intestine intestine decreased size , abnormal
intestine decreased volume , abnormal
intestine mucus layer decreased thickness , abnormal
intestine leukocyte increased amount , abnormal
Show

 ZFA:0005091 hepatic sinusoid hepatic sinusoid decreased size , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium decreased thickness , abnormal
Show

 ZFA:0005125 intestinal villus intestinal villus damage , abnormal
Show

 ZFA:0005739 pancreatic acinar cell pancreatic acinar cell endoplasmic reticulum lumen distended , abnormal
Show

 ZFA:0009094 goblet cell goblet cell cytoskeleton disorganized , abnormal
goblet cell exocytic vesicle morphology , abnormal
goblet cell increased amount , abnormal
goblet cell mislocalised , abnormal
goblet cell disorganized , abnormal
goblet cell detached from intestinal epithelium , abnormal
goblet cell condensed nuclear chromosome increased amount , abnormal
Show

 ZFA:0009097 enteroendocrine cell enteroendocrine cell autophagosome increased amount , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte apoptotic , abnormal
hepatocyte necrotic , abnormal
hepatocyte vacuolated , abnormal
hepatocyte fatty , abnormal
hepatocyte nucleus mislocalised , abnormal
hepatocyte mitochondrion morphology , abnormal
hepatocyte endoplasmic reticulum lumen vacuolated , abnormal
hepatocyte endoplasmic reticulum lumen swollen , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell nuclear chromatin condensed , abnormal
eye photoreceptor cell decreased amount , abnormal
Show

 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell shape , abnormal
intestinal epithelial cell apoptotic , abnormal
intestinal epithelial cell disorganized , abnormal
intestinal epithelial cell detached from intestinal epithelium , abnormal
intestinal epithelial cell brush border decreased thickness , abnormal
intestinal epithelial cell vesicle increased amount , abnormal
intestinal epithelial cell vesicle increased size , abnormal
intestinal epithelial cell autophagy of mitochondrion increased process quality , abnormal
intestinal epithelial cell cytoplasm immature , abnormal
intestinal epithelial cell mitochondrion morphology , abnormal
intestinal epithelial cell mitochondrion decreased amount , abnormal
intestinal epithelial cell autophagosome increased amount , abnormal
intestinal epithelial cell endoplasmic reticulum distended , abnormal
intestinal epithelial cell endoplasmic reticulum lumen vacuolated , abnormal
intestinal epithelial cell endoplasmic reticulum lumen distended , abnormal
intestinal epithelial cell Golgi apparatus distended , abnormal
intestinal epithelial cell brush border morphology , abnormal
intestinal epithelial cell brush border atrophied , abnormal
intestinal epithelial cell autophagy increased occurrence , abnormal
intestinal epithelial cell cell proliferation decreased process quality , abnormal
intestinal epithelial cell cortical actin cytoskeleton decreased thickness , abnormal
intestinal epithelial cell positive regulation of autophagy in response to ER overload increased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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