ENSDARG00000102417


Danio rerio

Features
Gene ID: ENSDARG00000102417
  
Biological name :psmd7
  
Synonyms : proteasome 26S subunit, non-ATPase 7 / psmd7
  
Possible biological names infered from orthology : P26516 / P51665 / proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 67307273
Gene end: 67317119
  
Corresponding Affymetrix probe sets: Dr.13173.1.S1_at (Zebrafish Array)   NM_199789_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000134068
Ensembl peptide - ENSDARP00000149302
NCBI entrez gene - 327330     See in Manteia.
RefSeq - NM_199789
RefSeq Peptide - NP_956083
swissprot - Q7ZYX7
ZFIN ID - ZDB-GENE-030131-5541
Ensembl - ENSDARG00000102417
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD7ENSGALG00000000707Gallus gallus
 PSMD7ENSG00000103035Homo sapiens
 Psmd7ENSMUSG00000039067Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif3f / eukaryotic translation initiation factor 3, subunit F / O00303* / Q9DCH4*ENSDARG0000007753324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR024969  Rpn11/EIF3F, C-terminal
 IPR033858  26S Proteasome non-ATPase regulatory subunit 7/8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0021551 central nervous system morphogenesis IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0000502 proteasome complex IBA
 cellular_componentGO:0005838 proteasome regulatory particle IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head immature , abnormal
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 ZFA:0001115 trunk trunk decreased thickness , abnormal
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 ZFA:0001117 post-vent region post-vent region malformed , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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