ENSDARG00000103092


Danio rerio

Features
Gene ID: ENSDARG00000103092
  
Biological name :grem2b
  
Synonyms : grem2b / gremlin 2, DAN family BMP antagonist b
  
Possible biological names infered from orthology : GREM2 / Gremlin-2 / gremlin 2, DAN family BMP antagonist / O88273 / Q9H772
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 47543832
Gene end: 47558276
  
Corresponding Affymetrix probe sets: Dr.19674.1.A1_at (Zebrafish Array)   NM_001017704_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000130610
NCBI entrez gene - 550399     See in Manteia.
RefSeq - NM_001017704
RefSeq Peptide - NP_001017704
swissprot - A0A0R4ICD7
ZFIN ID - ZDB-GENE-030911-9
Ensembl - ENSDARG00000103092
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GREM2ENSGALG00000010773Gallus gallus
 GREM2ENSG00000180875Homo sapiens
 Grem2ENSMUSG00000050069Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grem2a / gremlin 2, DAN family BMP antagonist a / GREM2* / Q9H772* / O88273* / Gremlin-2 * / gremlin 2, DAN family BMP antagonist*ENSDARG0000005605764
grem1b / gremlin 1b / GREM1* / O60565* / O70326* / Gremlin-1 * / gremlin 1, DAN family BMP antagonist*ENSDARG0000010461849
grem1a / gremlin 1a, DAN family BMP antagonist / GREM1* / O60565* / gremlin 1, DAN family BMP antagonist*ENSDARG0000009072045
grem1a / gremlin 1a, DAN family BMP antagonist / GREM1* / O60565* / O70326* / Gremlin-1 * / gremlin 1, DAN family BMP antagonist*ENSDARG0000002954645
CABZ01085139.1 / NBL1* / P41271* / neuroblastoma 1, DAN family BMP antagonist*ENSDARG000001026877


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR017159  Gremlin-1/2
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003205 cardiac chamber development IMP
 biological_processGO:0003230 cardiac atrium development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0061312 BMP signaling pathway involved in heart development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle morphology , abnormal
Show

 ZFA:0000250 opercle opercle malformed , abnormal
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 ZFA:0000360 heart tube heart tube decreased length , abnormal
heart tube decreased thickness , abnormal
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 ZFA:0000471 atrium atrium decreased size , abnormal
atrium deformed , abnormal
Show

 ZFA:0000672 hyomandibula hyomandibula absent , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 malformed , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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