ENSG00000180875


Homo sapiens

Features
Gene ID: ENSG00000180875
  
Biological name :GREM2
  
Synonyms : GREM2 / gremlin 2, DAN family BMP antagonist / Q9H772
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q43
Gene start: 240489573
Gene end: 240612149
  
Corresponding Affymetrix probe sets: 220794_at (Human Genome U133 Plus 2.0 Array)   235504_at (Human Genome U133 Plus 2.0 Array)   240509_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000318650
NCBI entrez gene - 64388     See in Manteia.
OMIM - 608832
RefSeq - XM_011544249
RefSeq - NM_022469
RefSeq - XM_005273226
RefSeq Peptide - NP_071914
swissprot - Q9H772
swissprot - A0A024R3Y1
Ensembl - ENSG00000180875
  
Related genetic diseases (OMIM): 617275 - Tooth agenesis, selective, 9, 617275
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grem2aENSDARG00000056057Danio rerio
 grem2bENSDARG00000103092Danio rerio
 GREM2ENSGALG00000010773Gallus gallus
 Grem2ENSMUSG00000050069Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GREM1 / O60565 / gremlin 1, DAN family BMP antagonistENSG0000016692357
NBL1 / P41271 / neuroblastoma 1, DAN family BMP antagonistENSG0000015874724


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR017159  Gremlin-1/2
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010172 embryonic body morphogenesis ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0038098 sequestering of BMP from receptor via BMP binding IEA
 biological_processGO:0048263 determination of dorsal identity IEA
 biological_processGO:0060300 regulation of cytokine activity ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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