ENSG00000166923


Homo sapiens

Features
Gene ID: ENSG00000166923
  
Biological name :GREM1
  
Synonyms : GREM1 / gremlin 1, DAN family BMP antagonist / O60565
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q13.3
Gene start: 32717974
Gene end: 32745107
  
Corresponding Affymetrix probe sets: 218468_s_at (Human Genome U133 Plus 2.0 Array)   218469_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478319
Ensembl peptide - ENSP00000453141
Ensembl peptide - ENSP00000453387
NCBI entrez gene - 26585     See in Manteia.
OMIM - 603054
RefSeq - XM_005254301
RefSeq - NM_001191322
RefSeq - NM_001191323
RefSeq - NM_013372
RefSeq Peptide - NP_001178251
RefSeq Peptide - NP_001178252
RefSeq Peptide - NP_037504
swissprot - A6XAA7
swissprot - H0YLY2
swissprot - O60565
Ensembl - ENSG00000166923
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grem1aENSDARG00000029546Danio rerio
 grem1aENSDARG00000090720Danio rerio
 grem1bENSDARG00000104618Danio rerio
 GREM1ENSGALG00000009724Gallus gallus
 Grem1ENSMUSG00000074934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GREM2 / Q9H772 / gremlin 2, DAN family BMP antagonistENSG0000018087552
NBL1 / P41271 / neuroblastoma 1, DAN family BMP antagonistENSG0000015874721


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR017159  Gremlin-1/2
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0002092 positive regulation of receptor internalization ISS
 biological_processGO:0002689 negative regulation of leukocyte chemotaxis IEA
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISS
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction ISS
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030502 negative regulation of bone mineralization IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IMP
 biological_processGO:0033689 negative regulation of osteoblast proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046851 negative regulation of bone remodeling IMP
 biological_processGO:0048263 determination of dorsal identity IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 biological_processGO:0051973 positive regulation of telomerase activity IDA
 biological_processGO:0060173 limb development IMP
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0060676 ureteric bud formation IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0090027 negative regulation of monocyte chemotaxis ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090291 negative regulation of osteoclast proliferation IMP
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation ISS
 biological_processGO:1900155 negative regulation of bone trabecula formation IMP
 biological_processGO:1900158 negative regulation of bone mineralization involved in bone maturation IMP
 biological_processGO:2000273 positive regulation of signaling receptor activity ISS
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space NAS
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016015 morphogen activity ISS
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity ISS
 molecular_functionGO:0036122 BMP binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding ISS
 molecular_functionGO:0048018 receptor ligand activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr