ENSMUSG00000074934


Mus musculus

Features
Gene ID: ENSMUSG00000074934
  
Biological name :Grem1
  
Synonyms : Grem1 / Gremlin-1 / O70326
  
Possible biological names infered from orthology : gremlin 1, DAN family BMP antagonist / O60565
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E4
Gene start: 113746164
Gene end: 113758646
  
Corresponding Affymetrix probe sets: 10485948 (MoGene1.0st)   1425357_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097170
NCBI entrez gene - 23892     See in Manteia.
MGI - MGI:1344337
RefSeq - NM_011824
RefSeq Peptide - NP_035954
swissprot - O70326
swissprot - Q3TNY7
Ensembl - ENSMUSG00000074934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grem1aENSDARG00000029546Danio rerio
 grem1aENSDARG00000090720Danio rerio
 grem1bENSDARG00000104618Danio rerio
 GREM1ENSGALG00000009724Gallus gallus
 GREM1ENSG00000166923Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grem2 / O88273 / Gremlin-2 / Q9H772* / gremlin 2, DAN family BMP antagonist*ENSMUSG0000005006951
Nbl1 / Q61477 / Neuroblastoma suppressor of tumorigenicity 1 / P41271* / neuroblastoma 1, DAN family BMP antagonist*ENSMUSG0000004112021


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR017159  Gremlin-1/2
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IGI
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0002689 negative regulation of leukocyte chemotaxis IEA
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IDA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043542 endothelial cell migration IDA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046851 negative regulation of bone remodeling IEA
 biological_processGO:0048263 determination of dorsal identity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060676 ureteric bud formation IDA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IDA
 biological_processGO:0090027 negative regulation of monocyte chemotaxis IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0090291 negative regulation of osteoclast proliferation IEA
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:1900155 negative regulation of bone trabecula formation IEA
 biological_processGO:1900158 negative regulation of bone mineralization involved in bone maturation IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IDA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity IDA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IPI
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding TAS
 molecular_functionGO:0048018 receptor ligand activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

Allelic Composition: Grem1ld-J/Grem1ld-J
Genetic Background: involves: CBA/Ca

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: involves: 129S1/SvImJ or CD-1

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Grem1tm1Ecan/Grem1+,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: involves: 129S1/SvImJ or CD-1

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0003604 single kidney 
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

Allelic Composition: Grem1ld-J/Grem1ld-J
Genetic Background: involves: CBA/Ca

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: involves: 129S1/SvImJ or CD-1

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0004639 fused metacarpal bones "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fmn1tm2Made/Fmn1+,Grem1tm1Azun/Grem1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0006281 abnormal tail development "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0006295 absent sclerotome "absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae" [J:60303, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj8slmbr/Kcnj8slmbr
Genetic Background: involves: C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj8slmbr/Kcnj8slmbr
Genetic Background: involves: C57BL/6J

 MP:0010982 abnormal ureteric bud elongation "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

Allelic Composition: Grem1ld-J/Grem1ld-J
Genetic Background: involves: CBA/Ca

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0011504 abnormal limb long bone morphology 
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm5Sia/Otx2tm5Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0011530 fused radius and ulna "anomaly of the radius and ulna resulting in some portion of or all the two bones being merged together" [MGI:csmith]
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Allelic Composition: Grem1ld/Grem1ld
Genetic Background: Not Specified

 MP:0011710 increased osteoblast differentiation 
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Allelic Composition: Kcnj8slmbr/Kcnj8slmbr
Genetic Background: involves: C57BL/6J

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Grem1tm1Ecan/Grem1+,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Grem1tm1Ecan/Grem1tm1Ecan,Nogtm1.1Rmh/Nogtm1.1Rmh,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Kcnj8slmbr/Kcnj8slmbr
Genetic Background: involves: C57BL/6J

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Kcnj8slmbr/Kcnj8slmbr
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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