ENSMUSG00000041120


Mus musculus

Features
Gene ID: ENSMUSG00000041120
  
Biological name :Nbl1
  
Synonyms : Nbl1 / Neuroblastoma suppressor of tumorigenicity 1 / Q61477
  
Possible biological names infered from orthology : neuroblastoma 1, DAN family BMP antagonist / P41271
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 139082284
Gene end: 139092993
  
Corresponding Affymetrix probe sets: 10517677 (MoGene1.0st)   1448428_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045608
NCBI entrez gene - 17965     See in Manteia.
MGI - MGI:104591
RefSeq - XM_006538626
RefSeq - NM_008675
RefSeq - XM_006538625
RefSeq Peptide - NP_032701
swissprot - Q61477
Ensembl - ENSMUSG00000041120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01085139.1ENSDARG00000102687Danio rerio
 NBL1ENSGALG00000040297Gallus gallus
 NBL1ENSG00000158747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grem2 / O88273 / Gremlin-2 / Q9H772* / gremlin 2, DAN family BMP antagonist*ENSMUSG0000005006924
Grem1 / O70326 / Gremlin-1 / O60565* / gremlin 1, DAN family BMP antagonist*ENSMUSG0000007493421


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR016728  Neuroblastoma suppressor of tumourigenicity 1
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0035582 sequestering of BMP in extracellular matrix IDA
 biological_processGO:0038098 sequestering of BMP from receptor via BMP binding IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0048263 determination of dorsal identity IMP
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0090027 negative regulation of monocyte chemotaxis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016015 morphogen activity IDA
 molecular_functionGO:0036122 BMP binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Bace1tm1Bux/Bace1tm1Bux
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syptm1Leu/Syptm1Leu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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