ENSGALG00000009724


Gallus gallus

Features
Gene ID: ENSGALG00000009724
  
Biological name :GREM1
  
Synonyms : GREM1 / Gremlin-1 / O73755
  
Possible biological names infered from orthology : gremlin 1, DAN family BMP antagonist / O60565 / O70326
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 30579487
Gene end: 30580185
  
Corresponding Affymetrix probe sets: Gga.2961.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037126
NCBI entrez gene - 395826     See in Manteia.
RefSeq - NM_204978
RefSeq Peptide - NP_990309
swissprot - O73755
Ensembl - ENSGALG00000009724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grem1aENSDARG00000029546Danio rerio
 grem1aENSDARG00000090720Danio rerio
 grem1bENSDARG00000104618Danio rerio
 GREM1ENSG00000166923Homo sapiens
 Grem1ENSMUSG00000074934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GREM2 / gremlin 2, DAN family BMP antagonist / O88273* / Q9H772* / Gremlin-2 *ENSGALG0000001077354
NBL1 / neuroblastoma 1, DAN family BMP antagonist / P41271* / Q61477* / Neuroblastoma suppressor of tumorigenicity 1 *ENSGALG0000004029721


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR017159  Gremlin-1/2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046851 negative regulation of bone remodeling IEA
 biological_processGO:0048263 determination of dorsal identity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060676 ureteric bud formation IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090291 negative regulation of osteoclast proliferation IEA
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:1900155 negative regulation of bone trabecula formation IEA
 biological_processGO:1900158 negative regulation of bone mineralization involved in bone maturation IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity IEA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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