ENSG00000003989


Homo sapiens

Features
Gene ID: ENSG00000003989
  
Biological name :SLC7A2
  
Synonyms : P52569 / SLC7A2 / solute carrier family 7 member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p22
Gene start: 17497088
Gene end: 17570573
  
Corresponding Affymetrix probe sets: 207626_s_at (Human Genome U133 Plus 2.0 Array)   225516_at (Human Genome U133 Plus 2.0 Array)   230658_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430464
Ensembl peptide - ENSP00000419873
Ensembl peptide - ENSP00000492016
Ensembl peptide - ENSP00000004531
Ensembl peptide - ENSP00000381164
Ensembl peptide - ENSP00000419140
NCBI entrez gene - 6542     See in Manteia.
OMIM - 601872
RefSeq - XM_017013747
RefSeq - NM_001008539
RefSeq - NM_001164771
RefSeq - NM_003046
RefSeq - XM_005273610
RefSeq - XM_005273611
RefSeq - XM_005273612
RefSeq - XM_017013746
RefSeq Peptide - NP_001008539
RefSeq Peptide - NP_001158243
RefSeq Peptide - NP_003037
swissprot - A0A1W2PR06
swissprot - P52569
Ensembl - ENSG00000003989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc7a2ENSDARG00000037097Danio rerio
 SLC7A2ENSGALG00000013627Gallus gallus
 P18581ENSMUSG00000031596Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P30825 / SLC7A1 / solute carrier family 7 member 1ENSG0000013951455
Q8WY07 / SLC7A3 / solute carrier family 7 member 3ENSG0000016534951
Q8TBB6 / SLC7A14 / solute carrier family 7 member 14ENSG0000001329339
O43246 / SLC7A4 / solute carrier family 7 member 4ENSG0000009996036


Protein motifs (from Interpro)
Interpro ID Name
 IPR002293  Amino acid/polyamine transporter I
 IPR004755  Cationic amino acid transport permease
 IPR029485  Cationic amino acid transporter, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002537 nitric oxide production involved in inflammatory response IEA
 biological_processGO:0006520 cellular amino acid metabolic process TAS
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0006865 amino acid transport TAS
 biological_processGO:0015809 arginine transport IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0043030 regulation of macrophage activation IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0097638 L-arginine import across plasma membrane IEA
 biological_processGO:0097639 L-lysine import across plasma membrane IEA
 biological_processGO:0097640 L-ornithine import across plasma membrane IEA
 biological_processGO:1902023 L-arginine transport IEA
 biological_processGO:1903352 L-ornithine transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0000064 L-ornithine transmembrane transporter activity IEA
 molecular_functionGO:0005289 high-affinity arginine transmembrane transporter activity IEA
 molecular_functionGO:0005292 high-affinity lysine transmembrane transporter activity IEA
 molecular_functionGO:0015171 amino acid transmembrane transporter activity TAS
 molecular_functionGO:0015174 basic amino acid transmembrane transporter activity TAS
 molecular_functionGO:0015181 arginine transmembrane transporter activity IEA
 molecular_functionGO:0015189 L-lysine transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0061459 L-arginine transmembrane transporter activity IEA
 molecular_functionGO:0097626 low-affinity L-arginine transmembrane transporter activity IEA
 molecular_functionGO:0097627 high-affinity L-ornithine transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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