ENSG00000004897


Homo sapiens

Features
Gene ID: ENSG00000004897
  
Biological name :CDC27
  
Synonyms : CDC27 / cell division cycle 27 / P30260
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 47117703
Gene end: 47189422
  
Corresponding Affymetrix probe sets: 217878_s_at (Human Genome U133 Plus 2.0 Array)   217879_at (Human Genome U133 Plus 2.0 Array)   217880_at (Human Genome U133 Plus 2.0 Array)   217881_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460830
Ensembl peptide - ENSP00000460454
Ensembl peptide - ENSP00000466424
Ensembl peptide - ENSP00000066544
Ensembl peptide - ENSP00000432105
Ensembl peptide - ENSP00000432211
Ensembl peptide - ENSP00000434614
Ensembl peptide - ENSP00000437339
Ensembl peptide - ENSP00000458904
Ensembl peptide - ENSP00000459307
Ensembl peptide - ENSP00000460061
Ensembl peptide - ENSP00000460132
Ensembl peptide - ENSP00000460279
Ensembl peptide - ENSP00000460424
NCBI entrez gene - 996     See in Manteia.
OMIM - 116946
RefSeq - XM_017025488
RefSeq - NM_001114091
RefSeq - NM_001256
RefSeq - NM_001293089
RefSeq - NM_001293091
RefSeq - NM_001353050
RefSeq - XM_011525546
RefSeq - XM_011525547
RefSeq - XM_011525548
RefSeq - XM_011525549
RefSeq - XM_011525550
RefSeq - XM_017025481
RefSeq - XM_017025482
RefSeq - XM_017025483
RefSeq - XM_017025484
RefSeq - XM_017025485
RefSeq - XM_017025486
RefSeq - XM_017025487
RefSeq Peptide - NP_001247
RefSeq Peptide - NP_001280018
RefSeq Peptide - NP_001280020
RefSeq Peptide - NP_001339979
RefSeq Peptide - NP_001107563
swissprot - I3L2Z8
swissprot - I3L328
swissprot - I3L394
swissprot - I3L3G1
swissprot - I3L3H6
swissprot - I3L3Y5
swissprot - K7EMA6
swissprot - E9PRZ6
swissprot - P30260
swissprot - F6QPS0
swissprot - G5EA36
swissprot - I3L1K3
swissprot - I3L225
Ensembl - ENSG00000004897
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc27ENSDARG00000056258Danio rerio
 CDC27ENSGALG00000000596Gallus gallus
 Cdc27ENSMUSG00000020687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005680 anaphase-promoting complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome TAS
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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