ENSMUSG00000020687


Mus musculus

Features
Gene ID: ENSMUSG00000020687
  
Biological name :Cdc27
  
Synonyms : A2A6Q5 / Cdc27 / Cell division cycle
  
Possible biological names infered from orthology : cell division cycle 27 / P30260
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 104502745
Gene end: 104550620
  
Corresponding Affymetrix probe sets: 10392012 (MoGene1.0st)   1426076_at (Mouse Genome 430 2.0 Array)   1433848_at (Mouse Genome 430 2.0 Array)   1433849_at (Mouse Genome 430 2.0 Array)   1454739_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091452
Ensembl peptide - ENSMUSP00000102574
Ensembl peptide - ENSMUSP00000102575
NCBI entrez gene - 217232     See in Manteia.
MGI - MGI:102685
RefSeq - XM_006533052
RefSeq - NM_001285988
RefSeq - NM_001285989
RefSeq - NM_001285990
RefSeq - NM_145436
RefSeq - XM_006533050
RefSeq - XM_006533051
RefSeq Peptide - NP_001272919
RefSeq Peptide - NP_663411
RefSeq Peptide - NP_001272917
RefSeq Peptide - NP_001272918
swissprot - Q8R568
swissprot - A2A6Q5
Ensembl - ENSMUSG00000020687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc27ENSDARG00000056258Danio rerio
 CDC27ENSGALG00000000596Gallus gallus
 CDC27ENSG00000004897Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR027363  Methylthioribose-1-phosphate isomerase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007091 metaphase/anaphase transition of mitotic cell cycle ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070979 protein K11-linked ubiquitination ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005680 anaphase-promoting complex ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005876 spindle microtubule ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019903 protein phosphatase binding ISO


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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