ENSG00000018280


Homo sapiens

Features
Gene ID: ENSG00000018280
  
Biological name :SLC11A1
  
Synonyms : P49279 / SLC11A1 / solute carrier family 11 member 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 218382029
Gene end: 218396894
  
Corresponding Affymetrix probe sets: 1555116_s_at (Human Genome U133 Plus 2.0 Array)   210422_x_at (Human Genome U133 Plus 2.0 Array)   210423_s_at (Human Genome U133 Plus 2.0 Array)   217473_x_at (Human Genome U133 Plus 2.0 Array)   217507_at (Human Genome U133 Plus 2.0 Array)   230382_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484905
Ensembl peptide - ENSP00000443435
Ensembl peptide - ENSP00000233202
Ensembl peptide - ENSP00000346320
Ensembl peptide - ENSP00000483970
NCBI entrez gene - 6556     See in Manteia.
OMIM - 600266
RefSeq - XM_017004767
RefSeq - XM_006712709
RefSeq - XM_006712710
RefSeq - XM_006712711
RefSeq - XM_011511684
RefSeq - XM_011511685
RefSeq - XM_017004765
RefSeq - XM_017004766
RefSeq - NM_000578
RefSeq - XM_005246793
RefSeq - XM_005246794
RefSeq Peptide - NP_000569
swissprot - A0A087X2D6
swissprot - A0A087X181
swissprot - A0A0A0MTL3
swissprot - P49279
swissprot - Q9HBK0
swissprot - A0A024R474
Ensembl - ENSG00000018280
  
Related genetic diseases (OMIM): 607948 - {Mycobacterium tuberculosis, susceptibility to infection by}, 607948
  610446 - {Buruli ulcer, susceptibility to}, 610446
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC11A1ENSGALG00000011434Gallus gallus
 P41251ENSMUSG00000026177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49281 / SLC11A2 / solute carrier family 11 member 2ENSG0000011091162


Protein motifs (from Interpro)
Interpro ID Name
 IPR001046  NRAMP family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production ISS
 biological_processGO:0001819 positive regulation of cytokine production ISS
 biological_processGO:0002309 T cell proliferation involved in immune response ISS
 biological_processGO:0002369 T cell cytokine production ISS
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006826 iron ion transport IMP
 biological_processGO:0006828 manganese ion transport ISS
 biological_processGO:0006876 cellular cadmium ion homeostasis IGI
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0006909 phagocytosis ISS
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007035 vacuolar acidification ISS
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0015707 nitrite transport ISS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0032147 activation of protein kinase activity ISS
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032623 interleukin-2 production ISS
 biological_processGO:0032632 interleukin-3 production ISS
 biological_processGO:0032729 positive regulation of interferon-gamma production ISS
 biological_processGO:0034341 response to interferon-gamma ISS
 biological_processGO:0042060 wound healing ISS
 biological_processGO:0042116 macrophage activation ISS
 biological_processGO:0042742 defense response to bacterium ISS
 biological_processGO:0042832 defense response to protozoan ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045342 MHC class II biosynthetic process ISS
 biological_processGO:0045454 cell redox homeostasis TAS
 biological_processGO:0045730 respiratory burst ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048002 antigen processing and presentation of peptide antigen ISS
 biological_processGO:0048255 mRNA stabilization ISS
 biological_processGO:0050766 positive regulation of phagocytosis ISS
 biological_processGO:0050829 defense response to Gram-negative bacterium ISS
 biological_processGO:0055072 iron ion homeostasis ISS
 biological_processGO:0060586 multicellular organismal iron ion homeostasis ISS
 biological_processGO:0070574 cadmium ion transmembrane transport IGI
 biological_processGO:0070839 divalent metal ion export ISS
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005770 late endosome ISS
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IDA
 cellular_componentGO:0031902 late endosome membrane TAS
 cellular_componentGO:0070821 tertiary granule membrane IDA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity ISS
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA
 molecular_functionGO:0046915 transition metal ion transmembrane transporter activity IGI
 molecular_functionGO:0051139 metal ion:proton antiporter activity TAS


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Metal ion SLC transporters
Neutrophil degranulation
Ion influx/efflux at host-pathogen interface


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001824 Weight loss 
Show

 HP:0001945 Fever 
Show

 HP:0002088 Abnormality of the lungs "An abnormality of the lungs or pulmonary system." [HPO:curators]
Show

 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
Show

 HP:0012735 Cough "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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