ENSG00000037897


Homo sapiens

Features
Gene ID: ENSG00000037897
  
Biological name :METTL1
  
Synonyms : methyltransferase like 1 / METTL1 / Q9UBP6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q14.1
Gene start: 57768471
Gene end: 57772793
  
Corresponding Affymetrix probe sets: 204027_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449397
Ensembl peptide - ENSP00000447988
Ensembl peptide - ENSP00000448342
Ensembl peptide - ENSP00000257848
Ensembl peptide - ENSP00000314441
Ensembl peptide - ENSP00000447838
NCBI entrez gene - 4234     See in Manteia.
OMIM - 604466
RefSeq - XM_017019305
RefSeq - NM_005371
RefSeq - NM_023033
RefSeq - XM_005268873
RefSeq Peptide - NP_075422
RefSeq Peptide - NP_005362
swissprot - H0YIH0
swissprot - Q9UBP6
swissprot - H0YHU4
swissprot - H0YHX0
swissprot - F8VSD9
Ensembl - ENSG00000037897
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mettl1ENSDARG00000076518Danio rerio
 Mettl1ENSMUSG00000006732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003358  tRNA (guanine-N-7) methyltransferase, Trmb type
 IPR025763  tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006400 tRNA modification IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0106004 tRNA (guanine-N7)-methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043527 tRNA methyltransferase complex IBA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008176 tRNA (guanine-N7-)-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
tRNA modification in the nucleus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160193 WDR4 / P57081 / WD repeat domain 4  / complex






 

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