ENSG00000047410


Homo sapiens

Features
Gene ID: ENSG00000047410
  
Biological name :TPR
  
Synonyms : P12270 / TPR / translocated promoter region, nuclear basket protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q31.1
Gene start: 186311652
Gene end: 186375693
  
Corresponding Affymetrix probe sets: 1557227_s_at (Human Genome U133 Plus 2.0 Array)   201730_s_at (Human Genome U133 Plus 2.0 Array)   201731_s_at (Human Genome U133 Plus 2.0 Array)   215220_s_at (Human Genome U133 Plus 2.0 Array)   228709_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000483425
Ensembl peptide - ENSP00000356448
Ensembl peptide - ENSP00000408103
NCBI entrez gene - 7175     See in Manteia.
OMIM - 189940
RefSeq - NM_003292
RefSeq Peptide - NP_003283
swissprot - P12270
swissprot - Q5SWX9
Ensembl - ENSG00000047410
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpraENSDARG00000103004Danio rerio
 tprbENSDARG00000016630Danio rerio
 TPRENSGALG00000005105Gallus gallus
 TprENSMUSG00000006005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012929  Nucleoprotein TPR/MLP1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000189 obsolete MAPK import into nucleus IMP
 biological_processGO:0006110 regulation of glycolytic process TAS
 biological_processGO:0006404 RNA import into nucleus IDA
 biological_processGO:0006405 RNA export from nucleus IMP
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006409 tRNA export from nucleus TAS
 biological_processGO:0006606 protein import into nucleus TAS
 biological_processGO:0006999 nuclear pore organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007094 mitotic spindle assembly checkpoint IMP
 biological_processGO:0010965 regulation of mitotic sister chromatid separation IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0031453 positive regulation of heterochromatin assembly IMP
 biological_processGO:0031990 mRNA export from nucleus in response to heat stress IDA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0035457 cellular response to interferon-alpha ISS
 biological_processGO:0042307 positive regulation of protein import into nucleus IMP
 biological_processGO:0045947 negative regulation of translational initiation IMP
 biological_processGO:0046827 positive regulation of protein export from nucleus ISS
 biological_processGO:0046832 negative regulation of RNA export from nucleus IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0070849 response to epidermal growth factor IDA
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
 biological_processGO:0090316 positive regulation of intracellular protein transport IMP
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901673 regulation of mitotic spindle assembly IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034399 nuclear periphery IDA
 cellular_componentGO:0042405 nuclear inclusion body IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0044615 nuclear pore nuclear basket IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0017056 structural constituent of nuclear pore IDA
 molecular_functionGO:0031072 heat shock protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IDA
 molecular_functionGO:0070840 dynein complex binding IDA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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