ENSMUSG00000006005


Mus musculus

Features
Gene ID: ENSMUSG00000006005
  
Biological name :Tpr
  
Synonyms : F6ZDS4 / Tpr / translocated promoter region, nuclear basket protein
  
Possible biological names infered from orthology : P12270
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G1
Gene start: 150392838
Gene end: 150449935
  
Corresponding Affymetrix probe sets: 10350535 (MoGene1.0st)   1426948_at (Mouse Genome 430 2.0 Array)   1426949_s_at (Mouse Genome 430 2.0 Array)   1456112_at (Mouse Genome 430 2.0 Array)   1456651_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112606
Ensembl peptide - ENSMUSP00000116012
Ensembl peptide - ENSMUSP00000117616
Ensembl peptide - ENSMUSP00000121991
NCBI entrez gene - 108989     See in Manteia.
MGI - MGI:1922066
RefSeq - XM_006529065
RefSeq - NM_133780
RefSeq Peptide - NP_598541
swissprot - F6RX08
swissprot - F6R5D8
swissprot - Q7M739
swissprot - F6ZDS4
Ensembl - ENSMUSG00000006005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpraENSDARG00000103004Danio rerio
 tprbENSDARG00000016630Danio rerio
 TPRENSGALG00000005105Gallus gallus
 TPRENSG00000047410Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012929  Nucleoprotein TPR/MLP1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000189 obsolete MAPK import into nucleus ISO
 biological_processGO:0006404 RNA import into nucleus IEA
 biological_processGO:0006405 RNA export from nucleus IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006913 nucleocytoplasmic transport IBA
 biological_processGO:0006999 nuclear pore organization ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0010965 regulation of mitotic sister chromatid separation IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031453 positive regulation of heterochromatin assembly IEA
 biological_processGO:0031990 mRNA export from nucleus in response to heat stress ISO
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035457 cellular response to interferon-alpha IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus ISO
 biological_processGO:0045947 negative regulation of translational initiation IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0046832 negative regulation of RNA export from nucleus IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070849 response to epidermal growth factor IEA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005643 nuclear pore ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 cellular_componentGO:0034399 nuclear periphery IEA
 cellular_componentGO:0042405 nuclear inclusion body IEA
 cellular_componentGO:0044615 nuclear pore nuclear basket IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0017056 structural constituent of nuclear pore IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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