ENSG00000061676


Homo sapiens

Features
Gene ID: ENSG00000061676
  
Biological name :NCKAP1
  
Synonyms : NCKAP1 / NCK associated protein 1 / Q9Y2A7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q32.1
Gene start: 182909115
Gene end: 183038858
  
Corresponding Affymetrix probe sets: 207738_s_at (Human Genome U133 Plus 2.0 Array)   217465_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354251
Ensembl peptide - ENSP00000355348
NCBI entrez gene - 10787     See in Manteia.
OMIM - 604891
RefSeq - XM_006712201
RefSeq - NM_013436
RefSeq - NM_205842
RefSeq - XM_006712200
RefSeq Peptide - NP_038464
RefSeq Peptide - NP_995314
swissprot - Q9Y2A7
Ensembl - ENSG00000061676
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0S6R1ENSDARG00000060853Danio rerio
 NCKAP1ENSGALG00000002750Gallus gallus
 Nckap1ENSMUSG00000027002Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P55160 / NCKAP1L / NCK associated protein 1 likeENSG0000012333858


Protein motifs (from Interpro)
Interpro ID Name
 IPR019137  Nck-associated protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0010592 positive regulation of lamellipodium assembly ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IDA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0031209 SCAR complex IDA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031941 filamentous actin ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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