ENSMUSG00000027002


Mus musculus

Features
Gene ID: ENSMUSG00000027002
  
Biological name :Nckap1
  
Synonyms : Mus musculus NCK-associated protein 1 (Nckap1), transcript variant 4, mRNA. / Nckap1 / P28660
  
Possible biological names infered from orthology : NCK associated protein 1 / Q9Y2A7
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 80500512
Gene end: 80581380
  
Corresponding Affymetrix probe sets: 10484318 (MoGene1.0st)   1452196_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028386
Ensembl peptide - ENSMUSP00000107390
NCBI entrez gene - 50884     See in Manteia.
MGI - MGI:1355333
RefSeq - NM_016965
RefSeq - XM_006499882
RefSeq - NM_001290745
RefSeq - NM_001355410
RefSeq - NM_001355411
RefSeq - XM_006499881
RefSeq Peptide - NP_001342339
RefSeq Peptide - NP_001342340
RefSeq Peptide - NP_058661
RefSeq Peptide - NP_001277674
swissprot - P28660
swissprot - A2AS98
Ensembl - ENSMUSG00000027002
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0S6R1ENSDARG00000060853Danio rerio
 NCKAP1ENSGALG00000002750Gallus gallus
 NCKAP1ENSG00000061676Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K1X4 / Nckap1l / Nck-associated protein 1-like / P55160*ENSMUSG0000002248858


Protein motifs (from Interpro)
Interpro ID Name
 IPR019137  Nck-associated protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007354 zygotic determination of anterior/posterior axis, embryo IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0008078 mesodermal cell migration IMP
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity IMP
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0045175 basal protein localization IDA
 biological_processGO:0045176 apical protein localization IDA
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0048340 paraxial mesoderm morphogenesis IMP
 biological_processGO:0048570 notochord morphogenesis IMP
 biological_processGO:0048617 embryonic foregut morphogenesis IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0031209 SCAR complex IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
Show

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011255 abnormal anterior visceral endoderm cell migration "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(RRQ139)Byg/Nckap1Gt(RRQ139)Byg
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
Show

Allelic Composition: Nckap1khlo/Nckap1khlo
Genetic Background: C3Fe.B6-Nckap1khlo

Allelic Composition: Nckap1Gt(XE068)Byg/Nckap1Gt(XE068)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nckap1Gt(XE133)Byg/Nckap1Gt(XE133)Byg
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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