ENSG00000062282


Homo sapiens

Features
Gene ID: ENSG00000062282
  
Biological name :DGAT2
  
Synonyms : DGAT2 / diacylglycerol O-acyltransferase 2 / Q96PD7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.5
Gene start: 75759512
Gene end: 75801535
  
Corresponding Affymetrix probe sets: 224327_s_at (Human Genome U133 Plus 2.0 Array)   226064_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475066
Ensembl peptide - ENSP00000228027
Ensembl peptide - ENSP00000474668
Ensembl peptide - ENSP00000474887
Ensembl peptide - ENSP00000365438
Ensembl peptide - ENSP00000474015
NCBI entrez gene - 84649     See in Manteia.
OMIM - 606983
RefSeq - XM_011545304
RefSeq - NM_001253891
RefSeq - NM_032564
RefSeq Peptide - NP_115953
RefSeq Peptide - NP_001240820
swissprot - S4R383
swissprot - S4R3Z3
swissprot - S4R449
swissprot - S4R3S3
swissprot - Q96PD7
Ensembl - ENSG00000062282
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgat2ENSDARG00000018846Danio rerio
 DGAT2ENSGALG00000040418Gallus gallus
 Dgat2ENSMUSG00000030747Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZPD8 / DGAT2L6 / diacylglycerol O-acyltransferase 2 like 6ENSG0000018421044
MOGAT3 / Q86VF5 / monoacylglycerol O-acyltransferase 3ENSG0000010638443
MOGAT1 / Q96PD6 / monoacylglycerol O-acyltransferase 1ENSG0000012400342
AWAT1 / Q58HT5 / acyl-CoA wax alcohol acyltransferase 1ENSG0000020419542
AWAT2 / Q6E213 / acyl-CoA wax alcohol acyltransferase 2ENSG0000014716041
MOGAT2 / Q3SYC2 / monoacylglycerol O-acyltransferase 2ENSG0000016639139


Protein motifs (from Interpro)
Interpro ID Name
 IPR007130  Diacylglycerol acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006071 glycerol metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process TAS
 biological_processGO:0019915 lipid storage ISS
 biological_processGO:0034383 low-density lipoprotein particle clearance ISS
 biological_processGO:0035336 long-chain fatty-acyl-CoA metabolic process IDA
 biological_processGO:0035356 cellular triglyceride homeostasis ISS
 biological_processGO:0036155 acylglycerol acyl-chain remodeling TAS
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0046322 negative regulation of fatty acid oxidation IEA
 biological_processGO:0046339 diacylglycerol metabolic process IDA
 biological_processGO:0050746 regulation of lipoprotein metabolic process IEA
 biological_processGO:0055089 fatty acid homeostasis ISS
 biological_processGO:0060613 fat pad development ISS
 biological_processGO:0071400 cellular response to oleic acid ISS
 biological_processGO:0090181 regulation of cholesterol metabolic process IEA
 biological_processGO:0097006 regulation of plasma lipoprotein particle levels ISS
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005811 lipid droplet ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0003846 2-acylglycerol O-acyltransferase activity IEA
 molecular_functionGO:0004144 diacylglycerol O-acyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0050252 retinol O-fatty-acyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of DAG and TAG
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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