ENSMUSG00000030747


Mus musculus

Features
Gene ID: ENSMUSG00000030747
  
Biological name :Dgat2
  
Synonyms : Dgat2 / Diacylglycerol O-acyltransferase 2 / Q9DCV3
  
Possible biological names infered from orthology : Q96PD7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E1
Gene start: 99153658
Gene end: 99182719
  
Corresponding Affymetrix probe sets: 10565775 (MoGene1.0st)   1422677_at (Mouse Genome 430 2.0 Array)   1422678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033001
Ensembl peptide - ENSMUSP00000147074
Ensembl peptide - ENSMUSP00000146391
Ensembl peptide - ENSMUSP00000146342
NCBI entrez gene - 67800     See in Manteia.
MGI - MGI:1915050
RefSeq - NM_026384
RefSeq Peptide - NP_080660
swissprot - A0A140LHF3
swissprot - A0A140LHA9
swissprot - A0A140LJ48
swissprot - Q9DCV3
Ensembl - ENSMUSG00000030747
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgat2ENSDARG00000018846Danio rerio
 DGAT2ENSGALG00000040418Gallus gallus
 DGAT2ENSG00000062282Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2ADU8 / Dgat2l6 / Diacylglycerol O-acyltransferase 2-like protein 6 / Q6ZPD8* / diacylglycerol O-acyltransferase 2 like 6*ENSMUSG0000006759741
Mogat2 / Q80W94 / 2-acylglycerol O-acyltransferase 2 / Q3SYC2* / monoacylglycerol O-acyltransferase 2*ENSMUSG0000005239641
Awat1 / A2ADU9 / Acyl-CoA wax alcohol acyltransferase 1 / Q58HT5*ENSMUSG0000001566541
Awat2 / Q6E1M8 / Acyl-CoA wax alcohol acyltransferase 2 / Q6E213*ENSMUSG0000003122040
Mogat1 / Q91ZV4 / 2-acylglycerol O-acyltransferase 1 / Q96PD6* / monoacylglycerol O-acyltransferase 1*ENSMUSG0000001218739


Protein motifs (from Interpro)
Interpro ID Name
 IPR007130  Diacylglycerol acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006071 glycerol metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process ISO
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0034383 low-density lipoprotein particle clearance IMP
 biological_processGO:0035336 long-chain fatty-acyl-CoA metabolic process IDA
 biological_processGO:0035356 cellular triglyceride homeostasis IMP
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0046322 negative regulation of fatty acid oxidation IEA
 biological_processGO:0046339 diacylglycerol metabolic process IEA
 biological_processGO:0050746 regulation of lipoprotein metabolic process IEA
 biological_processGO:0055089 fatty acid homeostasis IGI
 biological_processGO:0060613 fat pad development IMP
 biological_processGO:0071400 cellular response to oleic acid IMP
 biological_processGO:0090181 regulation of cholesterol metabolic process IEA
 biological_processGO:0097006 regulation of plasma lipoprotein particle levels IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003846 2-acylglycerol O-acyltransferase activity IDA
 molecular_functionGO:0004144 diacylglycerol O-acyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0050252 retinol O-fatty-acyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of DAG and TAG
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

Allelic Composition: Dgat2tm1Lex/Dgat2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

Allelic Composition: Dgat2tm1Lex/Dgat2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0005285 decreased unsaturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dgat2tm1Lex/Dgat2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0009608 abnormal lamellar body morphology "any structural anomaly of a membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dgat2tm1Lex/Dgat2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

 MP:0013178 tail necrosis "morphological changes resulting from pathological death of tail tissue; usually due to irreversible damage" [MGI:anna]
Show

Allelic Composition: Trfhpx/Trf+
Genetic Background: BALB/cJ-Trfhpx

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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