ENSMUSG00000012187


Mus musculus

Features
Gene ID: ENSMUSG00000012187
  
Biological name :Mogat1
  
Synonyms : 2-acylglycerol O-acyltransferase 1 / Mogat1 / Q91ZV4
  
Possible biological names infered from orthology : monoacylglycerol O-acyltransferase 1 / Q96PD6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 78510991
Gene end: 78538173
  
Corresponding Affymetrix probe sets: 10347741 (MoGene1.0st)   1419504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109152
Ensembl peptide - ENSMUSP00000123427
Ensembl peptide - ENSMUSP00000117903
Ensembl peptide - ENSMUSP00000116178
Ensembl peptide - ENSMUSP00000012331
NCBI entrez gene - 68393     See in Manteia.
MGI - MGI:1915643
RefSeq - XM_011238707
RefSeq - XM_017322285
RefSeq - XM_017322283
RefSeq - NM_026713
RefSeq - XM_017322281
RefSeq Peptide - NP_080989
swissprot - Q91ZV4
swissprot - D3Z6K9
swissprot - D3YW64
swissprot - D3YZB8
Ensembl - ENSMUSG00000012187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mogat3aENSDARG00000086481Danio rerio
 MOGAT1ENSGALG00000005217Gallus gallus
 MOGAT1ENSG00000124003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mogat2 / Q80W94 / 2-acylglycerol O-acyltransferase 2 / Q3SYC2* / monoacylglycerol O-acyltransferase 2*ENSMUSG0000005239653
Dgat2 / Q9DCV3 / Diacylglycerol O-acyltransferase 2 / Q96PD7*ENSMUSG0000003074745
A2ADU8 / Dgat2l6 / Diacylglycerol O-acyltransferase 2-like protein 6 / Q6ZPD8* / diacylglycerol O-acyltransferase 2 like 6*ENSMUSG0000006759741
Awat1 / A2ADU9 / Acyl-CoA wax alcohol acyltransferase 1 / Q58HT5*ENSMUSG0000001566539
Awat2 / Q6E1M8 / Acyl-CoA wax alcohol acyltransferase 2 / Q6E213*ENSMUSG0000003122037


Protein motifs (from Interpro)
Interpro ID Name
 IPR007130  Diacylglycerol acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006071 glycerol metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006651 diacylglycerol biosynthetic process IDA
 biological_processGO:0019432 triglyceride biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003846 2-acylglycerol O-acyltransferase activity IDA
 molecular_functionGO:0004144 diacylglycerol O-acyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA


Pathways (from Reactome)
Pathway description
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdh23tm1.1Kjn/Cdh23tm1.1Kjn
Genetic Background: 129S/Sv-Cdh23tm1.1Kjn/Kjn

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Agpat2tm1Garg/Agpat2tm1Garg,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr