ENSG00000063854


Homo sapiens

Features
Gene ID: ENSG00000063854
  
Biological name :HAGH
  
Synonyms : HAGH / hydroxyacylglutathione hydrolase / Q16775
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 1795620
Gene end: 1827194
  
Corresponding Affymetrix probe sets: 205012_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457986
Ensembl peptide - ENSP00000455422
Ensembl peptide - ENSP00000455970
Ensembl peptide - ENSP00000380511
Ensembl peptide - ENSP00000380514
Ensembl peptide - ENSP00000406552
Ensembl peptide - ENSP00000455355
NCBI entrez gene - 3029     See in Manteia.
OMIM - 138760
RefSeq - XM_017023195
RefSeq - NM_001040427
RefSeq - NM_001286249
RefSeq - NM_005326
RefSeq - XM_011522469
RefSeq - XM_011522470
RefSeq Peptide - NP_001035517
RefSeq Peptide - NP_005317
RefSeq Peptide - NP_001273178
swissprot - H3BV79
swissprot - H3BPK3
swissprot - Q16775
swissprot - H3BPQ4
swissprot - H3BQW8
Ensembl - ENSG00000063854
  
Related genetic diseases (OMIM): 614033 - [Glyoxalase II deficiency], 614033
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 haghENSDARG00000025338Danio rerio
 HAGHENSGALG00000005398Gallus gallus
 HaghENSMUSG00000024158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HAGHL / Q6PII5 / hydroxyacylglutathione hydrolase likeENSG0000010325342
PNKD / Q8N490 / paroxysmal nonkinesigenic dyskinesiaENSG0000012783838
ETHE1 / O95571 / ETHE1, persulfide dioxygenaseENSG0000010575518


Protein motifs (from Interpro)
Interpro ID Name
 IPR001279  Metallo-beta-lactamase
 IPR017782  Hydroxyacylglutathione hydrolase
 IPR032282  Hydroxyacylglutathione hydrolase, C-terminal domain
 IPR035680  Hydroxyacylglutathione hydrolase, MBL domain
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process TAS
 biological_processGO:0006750 glutathione biosynthetic process IDA
 biological_processGO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004416 hydroxyacylglutathione hydrolase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr