ENSG00000068028


Homo sapiens

Features
Gene ID: ENSG00000068028
  
Biological name :RASSF1
  
Synonyms : Q9NS23 / Ras association domain family member 1 / RASSF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 50329782
Gene end: 50340980
  
Corresponding Affymetrix probe sets: 204346_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482696
Ensembl peptide - ENSP00000333327
Ensembl peptide - ENSP00000349547
Ensembl peptide - ENSP00000352323
Ensembl peptide - ENSP00000378549
Ensembl peptide - ENSP00000378558
Ensembl peptide - ENSP00000433000
NCBI entrez gene - 11186     See in Manteia.
OMIM - 605082
RefSeq - XM_011533316
RefSeq - NM_001206957
RefSeq - NM_007182
RefSeq - NM_170712
RefSeq - NM_170713
RefSeq - NM_170714
RefSeq - XM_011533315
RefSeq Peptide - NP_733830
RefSeq Peptide - NP_733831
RefSeq Peptide - NP_733832
RefSeq Peptide - NP_001193886
RefSeq Peptide - NP_009113
swissprot - Q9NS23
Ensembl - ENSG00000068028
  
Related genetic diseases (OMIM): 211980 - Lung cancer, 211980
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rassf1ENSDARG00000004840Danio rerio
 RASSF1ENSGALG00000038951Gallus gallus
 Q99MK9ENSMUSG00000010067Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8WWW0 / RASSF5 / Ras association domain family member 5ENSG0000026609443
Q86WH2 / RASSF3 / Ras association domain family member 3ENSG0000015317927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011524  SARAH domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033600  Ras association domain-containing protein 1
 IPR033614  C-terminal RASSF family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0006519 Alveolar cell carcinoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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