ENSG00000087250


Homo sapiens

Features
Gene ID: ENSG00000087250
  
Biological name :MT3
  
Synonyms : metallothionein 3 / MT3 / P25713
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q13
Gene start: 56589074
Gene end: 56591088
  
Corresponding Affymetrix probe sets: 205970_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455980
Ensembl peptide - ENSP00000457164
Ensembl peptide - ENSP00000200691
Ensembl peptide - ENSP00000455353
NCBI entrez gene - 4504     See in Manteia.
OMIM - 139255
RefSeq - NM_005954
RefSeq Peptide - NP_005945
swissprot - H3BQX6
swissprot - A0A024R6R7
swissprot - P25713
swissprot - H3BTG5
swissprot - H3BPK2
Ensembl - ENSG00000087250
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Mt3ENSMUSG00000031760Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000006  Metallothionein, vertebrate
 IPR003019  Metallothionein
 IPR017854  Metallothionein domain superfamily
 IPR018064  Metallothionein, vertebrate, metal binding site
 IPR023587  Metallothionein domain superfamily, vertebrate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006112 energy reserve metabolic process ISS
 biological_processGO:0006707 cholesterol catabolic process ISS
 biological_processGO:0006829 zinc ion transport ISS
 biological_processGO:0006875 cellular metal ion homeostasis TAS
 biological_processGO:0006882 cellular zinc ion homeostasis ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010038 response to metal ion TAS
 biological_processGO:0010507 negative regulation of autophagy ISS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010940 positive regulation of necrotic cell death IDA
 biological_processGO:0010942 positive regulation of cell death ISS
 biological_processGO:0014002 astrocyte development ISS
 biological_processGO:0016570 histone modification IMP
 biological_processGO:0019430 removal of superoxide radicals IDA
 biological_processGO:0030308 negative regulation of cell growth TAS
 biological_processGO:0030517 negative regulation of axon extension IDA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0032095 regulation of response to food ISS
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0033210 leptin-mediated signaling pathway ISS
 biological_processGO:0034599 cellular response to oxidative stress IEP
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043085 positive regulation of catalytic activity ISS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043491 protein kinase B signaling IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0044242 cellular lipid catabolic process ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051354 negative regulation of oxidoreductase activity IDA
 biological_processGO:0055069 zinc ion homeostasis IDA
 biological_processGO:0055073 cadmium ion homeostasis IDA
 biological_processGO:0060049 regulation of protein glycosylation ISS
 biological_processGO:0060547 negative regulation of necrotic cell death ISS
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071276 cellular response to cadmium ion IDA
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0071732 cellular response to nitric oxide IDA
 biological_processGO:0097214 positive regulation of lysosomal membrane permeability ISS
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IDA
 biological_processGO:2000296 negative regulation of hydrogen peroxide catabolic process IEA
 biological_processGO:2000376 positive regulation of oxygen metabolic process ISS
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016234 inclusion body IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:0097450 astrocyte end-foot IEA
 molecular_functionGO:0005507 copper ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016209 antioxidant activity NAS
 molecular_functionGO:0030295 protein kinase activator activity IDA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
 molecular_functionGO:0046870 cadmium ion binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metallothioneins bind metals


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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