ENSMUSG00000031760


Mus musculus

Features
Gene ID: ENSMUSG00000031760
  
Biological name :Mt3
  
Synonyms : Metallothionein-3 / Mt3 / P28184
  
Possible biological names infered from orthology : P25713
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 94152607
Gene end: 94154146
  
Corresponding Affymetrix probe sets: 10574018 (MoGene1.0st)   1420575_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034211
Ensembl peptide - ENSMUSP00000148383
Ensembl peptide - ENSMUSP00000148345
NCBI entrez gene - 17751     See in Manteia.
MGI - MGI:97173
RefSeq - NM_013603
RefSeq Peptide - NP_038631
swissprot - A0A1D5RLF4
swissprot - A0A1D5RLI5
swissprot - P28184
swissprot - Q3USP9
Ensembl - ENSMUSG00000031760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MT3ENSG00000087250Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000006  Metallothionein, vertebrate
 IPR003019  Metallothionein
 IPR017854  Metallothionein domain superfamily
 IPR018064  Metallothionein, vertebrate, metal binding site
 IPR023587  Metallothionein domain superfamily, vertebrate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0006707 cholesterol catabolic process IMP
 biological_processGO:0006829 zinc ion transport IDA
 biological_processGO:0006875 cellular metal ion homeostasis IDA
 biological_processGO:0006882 cellular zinc ion homeostasis IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014002 astrocyte development IDA
 biological_processGO:0016570 histone modification IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0032095 regulation of response to food IMP
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0033210 leptin-mediated signaling pathway IMP
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0044242 cellular lipid catabolic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0050768 negative regulation of neurogenesis IDA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051354 negative regulation of oxidoreductase activity IEA
 biological_processGO:0055069 zinc ion homeostasis IEA
 biological_processGO:0055073 cadmium ion homeostasis IMP
 biological_processGO:0060049 regulation of protein glycosylation IMP
 biological_processGO:0060547 negative regulation of necrotic cell death IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0097214 positive regulation of lysosomal membrane permeability IMP
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IEA
 biological_processGO:2000296 negative regulation of hydrogen peroxide catabolic process IEA
 biological_processGO:2000376 positive regulation of oxygen metabolic process IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016234 inclusion body IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:0097450 astrocyte end-foot IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0046870 cadmium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metallothioneins bind metals


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000192 abnormal mineral level "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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