ENSG00000089053


Homo sapiens

Features
Gene ID: ENSG00000089053
  
Biological name :ANAPC5
  
Synonyms : ANAPC5 / anaphase promoting complex subunit 5 / Q9UJX4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 121308245
Gene end: 121399896
  
Corresponding Affymetrix probe sets: 200098_s_at (Human Genome U133 Plus 2.0 Array)   208721_s_at (Human Genome U133 Plus 2.0 Array)   208722_s_at (Human Genome U133 Plus 2.0 Array)   211036_x_at (Human Genome U133 Plus 2.0 Array)   235926_at (Human Genome U133 Plus 2.0 Array)   239651_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445191
Ensembl peptide - ENSP00000440800
Ensembl peptide - ENSP00000441508
Ensembl peptide - ENSP00000261819
Ensembl peptide - ENSP00000415061
Ensembl peptide - ENSP00000437857
Ensembl peptide - ENSP00000438754
Ensembl peptide - ENSP00000439875
NCBI entrez gene - 51433     See in Manteia.
OMIM - 606948
RefSeq - XM_017019424
RefSeq - NM_001137559
RefSeq - NM_001330489
RefSeq - NM_016237
RefSeq - XM_005253900
RefSeq - XM_017019423
RefSeq Peptide - NP_001131031
RefSeq Peptide - NP_001317418
RefSeq Peptide - NP_057321
swissprot - F5GZ05
swissprot - F5H0F9
swissprot - F5H0N1
swissprot - F5H3S5
swissprot - H0YFB5
swissprot - Q9UJX4
swissprot - F5GY68
Ensembl - ENSG00000089053
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anapc5ENSDARG00000008461Danio rerio
 ANAPC5ENSGALG00000004179Gallus gallus
 Anapc5ENSMUSG00000029472Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR019734  Tetratricopeptide repeat
 IPR026000  Anaphase-promoting complex subunit 5 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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