ENSG00000089060


Homo sapiens

Features
Gene ID: ENSG00000089060
  
Biological name :SLC8B1
  
Synonyms : Q6J4K2 / SLC8B1 / solute carrier family 8 member B1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.13
Gene start: 113298759
Gene end: 113359493
  
Corresponding Affymetrix probe sets: 218749_s_at (Human Genome U133 Plus 2.0 Array)   222727_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449519
Ensembl peptide - ENSP00000449448
Ensembl peptide - ENSP00000450081
Ensembl peptide - ENSP00000202831
Ensembl peptide - ENSP00000447091
Ensembl peptide - ENSP00000447502
Ensembl peptide - ENSP00000447585
Ensembl peptide - ENSP00000447972
Ensembl peptide - ENSP00000448703
Ensembl peptide - ENSP00000448749
Ensembl peptide - ENSP00000448758
NCBI entrez gene - 80024     See in Manteia.
OMIM - 609841
RefSeq - XM_017019978
RefSeq - NM_001358345
RefSeq - NM_024959
RefSeq - XM_006719607
RefSeq - XM_011538749
RefSeq - XM_011538750
RefSeq - XM_011538752
RefSeq Peptide - NP_001317395
RefSeq Peptide - NP_001345274
RefSeq Peptide - NP_079235
swissprot - F8VTU4
swissprot - F8VW44
swissprot - F8VWW9
swissprot - F8W134
swissprot - Q6J4K2
swissprot - H0YI75
swissprot - A0A0B4J252
swissprot - F8VR99
Ensembl - ENSG00000089060
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc8b1ENSDARG00000105584Danio rerio
 F1NXU8ENSGALG00000008337Gallus gallus
 Q925Q3ENSMUSG00000032754Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60721 / SLC24A1 / solute carrier family 24 member 1ENSG0000007462123
Q9UI40 / SLC24A2 / solute carrier family 24 member 2ENSG0000015588622
Q9HC58 / SLC24A3 / solute carrier family 24 member 3ENSG0000018505222
Q8NFF2 / SLC24A4 / solute carrier family 24 member 4ENSG0000014009020
Q71RS6 / SLC24A5 / solute carrier family 24 member 5ENSG0000018846718


Protein motifs (from Interpro)
Interpro ID Name
 IPR004837  Sodium/calcium exchanger membrane region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport TAS
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0050796 regulation of insulin secretion IDA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential TAS
 biological_processGO:0099093 calcium export from the mitochondrion IDA
 biological_processGO:1901623 regulation of lymphocyte chemotaxis ISS
 biological_processGO:2001256 regulation of store-operated calcium entry IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030061 mitochondrial crista IDA
 cellular_componentGO:0032592 integral component of mitochondrial membrane IDA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0005432 calcium:sodium antiporter activity TAS
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015368 calcium:cation antiporter activity TAS
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential TAS


Pathways (from Reactome)
Pathway description
Sodium/Calcium exchangers
Mitochondrial calcium ion transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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