ENSMUSG00000032754


Mus musculus

Features
Gene ID: ENSMUSG00000032754
  
Biological name :Slc8b1
  
Synonyms : Q925Q3 / Slc8b1 / solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
  
Possible biological names infered from orthology : Q6J4K2 / solute carrier family 8 member B1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 120511168
Gene end: 120534024
  
Corresponding Affymetrix probe sets: 10525086 (MoGene1.0st)   1417811_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117260
Ensembl peptide - ENSMUSP00000107521
Ensembl peptide - ENSMUSP00000120947
Ensembl peptide - ENSMUSP00000064714
Ensembl peptide - ENSMUSP00000075428
Ensembl peptide - ENSMUSP00000107520
NCBI entrez gene - 170756     See in Manteia.
MGI - MGI:2180781
RefSeq - XM_017320692
RefSeq - NM_001177594
RefSeq - NM_001177595
RefSeq - NM_133221
RefSeq - XM_006530174
RefSeq - XM_006530175
RefSeq Peptide - NP_001171066
RefSeq Peptide - NP_573484
RefSeq Peptide - NP_001171065
swissprot - D3Z5E7
swissprot - Q925Q3
swissprot - D3Z226
Ensembl - ENSMUSG00000032754
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc8b1ENSDARG00000105584Danio rerio
 F1NXU8ENSGALG00000008337Gallus gallus
 Q6J4K2ENSG00000089060Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc24a1 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 / O60721* / solute carrier family 24 member 1*ENSMUSG0000003445223
Slc24a2 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 / Q9UI40* / solute carrier family 24 member 2*ENSMUSG0000003799622
Q99PD7 / Slc24a3 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 / Q9HC58* / solute carrier family 24 member 3*ENSMUSG0000006387321
Slc24a4 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 / Q8NFF2* / solute carrier family 24 member 4*ENSMUSG0000004177119
Q8C261 / Slc24a5 / solute carrier family 24, member 5 / Q71RS6*ENSMUSG0000003518318


Protein motifs (from Interpro)
Interpro ID Name
 IPR004837  Sodium/calcium exchanger membrane region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IMP
 biological_processGO:0035725 sodium ion transmembrane transport IDA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0050796 regulation of insulin secretion ISO
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IDA
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential IEA
 biological_processGO:0099093 calcium export from the mitochondrion IMP
 biological_processGO:1901623 regulation of lymphocyte chemotaxis IMP
 biological_processGO:2001256 regulation of store-operated calcium entry ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030061 mitochondrial crista ISS
 cellular_componentGO:0032592 integral component of mitochondrial membrane ISO
 cellular_componentGO:0042383 sarcolemma ISO
 molecular_functionGO:0005432 calcium:sodium antiporter activity ISO
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential IMP


Pathways (from Reactome)
Pathway description
Sodium/Calcium exchangers
Mitochondrial calcium ion transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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