ENSMUSG00000041771


Mus musculus

Features
Gene ID: ENSMUSG00000041771
  
Biological name :Slc24a4
  
Synonyms : Slc24a4 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
  
Possible biological names infered from orthology : Q8NFF2 / solute carrier family 24 member 4
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 102128733
Gene end: 102267091
  
Corresponding Affymetrix probe sets: 10397835 (MoGene1.0st)   1435206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078030
Ensembl peptide - ENSMUSP00000125012
Ensembl peptide - ENSMUSP00000124513
NCBI entrez gene - 238384     See in Manteia.
MGI - MGI:2447362
RefSeq - NM_172152
RefSeq - XM_006515854
RefSeq Peptide - NP_742164
swissprot - A0A0R4J0Z4
swissprot - F7B0S9
swissprot - E9PUL6
Ensembl - ENSMUSG00000041771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc24a4aENSDARG00000015425Danio rerio
 slc24a4bENSDARG00000067509Danio rerio
 SLC24A4ENSGALG00000010793Gallus gallus
 Q8NFF2ENSG00000140090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99PD7 / Slc24a3 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 / Q9HC58* / solute carrier family 24 member 3*ENSMUSG0000006387359
Slc24a2 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 / Q9UI40* / solute carrier family 24 member 2*ENSMUSG0000003799635
Slc24a1 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 / O60721* / solute carrier family 24 member 1*ENSMUSG0000003445235
Q8C261 / Slc24a5 / solute carrier family 24, member 5 / Q71RS6*ENSMUSG0000003518331
Q925Q3 / Slc8b1 / solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 / Q6J4K2* / solute carrier family 8 member B1*ENSMUSG0000003275419


Protein motifs (from Interpro)
Interpro ID Name
 IPR004481  Sodium/potassium/calcium exchanger
 IPR004837  Sodium/calcium exchanger membrane region
 IPR030232  Sodium/potassium/calcium exchanger 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008273 calcium, potassium:sodium antiporter activity IEA


Pathways (from Reactome)
Pathway description
Sodium/Calcium exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omptm4(cre)Mom
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1.1Manf/Trp53tm1.1Manf
Genetic Background: Not Specified

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0009562 abnormal odor adaptation "altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0030450 abnormal enamel mineralization "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the dental enamel" [GO:0070166]
Show

Allelic Composition: Trp53tm1.1Manf/Trp53tm1.1Manf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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