ENSMUSG00000035183


Mus musculus

Features
Gene ID: ENSMUSG00000035183
  
Biological name :Slc24a5
  
Synonyms : Q8C261 / Slc24a5 / solute carrier family 24, member 5
  
Possible biological names infered from orthology : Q71RS6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 125068124
Gene end: 125088677
  
Corresponding Affymetrix probe sets: 10475567 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000063887
NCBI entrez gene - 317750     See in Manteia.
MGI - MGI:2677271
RefSeq - NM_175034
RefSeq Peptide - NP_778199
swissprot - A2ATP8
swissprot - Q8C261
Ensembl - ENSMUSG00000035183
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc24a5ENSDARG00000024771Danio rerio
 SLC24A5ENSGALG00000004885Gallus gallus
 Q71RS6ENSG00000188467Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99PD7 / Slc24a3 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 / Q9HC58* / solute carrier family 24 member 3*ENSMUSG0000006387337
Slc24a4 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 / Q8NFF2* / solute carrier family 24 member 4*ENSMUSG0000004177137
Slc24a1 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 / O60721* / solute carrier family 24 member 1*ENSMUSG0000003445235
Slc24a2 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 / Q9UI40* / solute carrier family 24 member 2*ENSMUSG0000003799634
Q925Q3 / Slc8b1 / solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 / Q6J4K2* / solute carrier family 8 member B1*ENSMUSG0000003275421


Protein motifs (from Interpro)
Interpro ID Name
 IPR004481  Sodium/potassium/calcium exchanger
 IPR004837  Sodium/calcium exchanger membrane region
 IPR030245  Sodium/potassium/calcium exchanger 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IBA
 biological_processGO:0034220 ion transmembrane transport ISO
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0048021 regulation of melanin biosynthetic process IEA
 biological_processGO:0048022 negative regulation of melanin biosynthetic process IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0008273 calcium, potassium:sodium antiporter activity IBA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0030955 potassium ion binding IBA
 molecular_functionGO:0031402 sodium ion binding IBA


Pathways (from Reactome)
Pathway description
Sodium/Calcium exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000015 abnormal ear pigmentation "anomaly in the coloration of the ear" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc20a2tm1b(EUCOMM)Wtsi/Slc20a2+
Genetic Background: C57BL/6N-Slc20a2tm1b(EUCOMM)Wtsi/Ieg

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0005101 abnormal ciliary body pigmentation "anomalous coloring of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0006159 ocular albinism "absence of melanin production in the eye only" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0006226 iris hypoplasia "less than the normal number of cells in the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0008731 abnormal hair shaft melanin granules "any amount or distribution anomaly of pigment polymers in the hair shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0009273 abnormal hair shaft melanin granule shape "the form of pigment polymers in the hair shaft differs compared to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0009385 abnormal dermal pigmentation "anomaly in coloration of the dermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0009387 abnormal epidermal pigmentation "anomaly in coloration of the epidermal layer of the skin in relation to control animals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0012122 abnormal iris transillumination "any anomaly in the radial light dispersion pattern of the iris when a focused light beam is passed through it; particular dispersion pattern anomalies are indicative of abnormalities in iris pigment distribution and for the presence of glaucoma, atrophy and/or infection" [MGI:csmith]
Show

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr