ENSMUSG00000037996


Mus musculus

Features
Gene ID: ENSMUSG00000037996
  
Biological name :Slc24a2
  
Synonyms : Slc24a2 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
  
Possible biological names infered from orthology : Q9UI40 / solute carrier family 24 member 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C4
Gene start: 86983124
Gene end: 87230477
  
Corresponding Affymetrix probe sets: 10514240 (MoGene1.0st)   1429225_at (Mouse Genome 430 2.0 Array)   1453885_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043937
Ensembl peptide - ENSMUSP00000102775
Ensembl peptide - ENSMUSP00000102776
Ensembl peptide - ENSMUSP00000119537
Ensembl peptide - ENSMUSP00000102773
NCBI entrez gene - 76376     See in Manteia.
MGI - MGI:1923626
RefSeq - XM_017320436
RefSeq - XM_006538344
RefSeq - XM_006538345
RefSeq - XM_006538346
RefSeq - XM_006538347
RefSeq - XM_006538348
RefSeq - XM_006538349
RefSeq - XM_017320435
RefSeq - NM_001110240
RefSeq - NM_172426
RefSeq - XM_006538342
RefSeq - XM_006538343
RefSeq Peptide - NP_766014
RefSeq Peptide - NP_001103710
swissprot - Q8BUN9
swissprot - F6RT95
swissprot - Q14BI1
swissprot - B1AXF2
swissprot - B1AXF3
Ensembl - ENSMUSG00000037996
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01081780.1ENSDARG00000063158Danio rerio
 slc24a2ENSDARG00000042988Danio rerio
 SLC24A2ENSGALG00000015080Gallus gallus
 Q9UI40ENSG00000155886Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc24a1 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 / O60721* / solute carrier family 24 member 1*ENSMUSG0000003445251
Slc24a4 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 / Q8NFF2* / solute carrier family 24 member 4*ENSMUSG0000004177130
Q99PD7 / Slc24a3 / solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 / Q9HC58* / solute carrier family 24 member 3*ENSMUSG0000006387329
Q8C261 / Slc24a5 / solute carrier family 24, member 5 / Q71RS6*ENSMUSG0000003518324
Q925Q3 / Slc8b1 / solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 / Q6J4K2* / solute carrier family 8 member B1*ENSMUSG0000003275418


Protein motifs (from Interpro)
Interpro ID Name
 IPR004481  Sodium/potassium/calcium exchanger
 IPR004837  Sodium/calcium exchanger membrane region
 IPR030236  Sodium/potassium/calcium exchanger 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 molecular_functionGO:0005262 calcium channel activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008273 calcium, potassium:sodium antiporter activity IBA
 molecular_functionGO:0016151 nickel cation binding IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0046870 cadmium ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Sodium/Calcium exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esx1tm1Bhr/Esx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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