ENSG00000090432


Homo sapiens

Features
Gene ID: ENSG00000090432
  
Biological name :MUL1
  
Synonyms : mitochondrial E3 ubiquitin protein ligase 1 / MUL1 / Q969V5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.12
Gene start: 20499448
Gene end: 20508161
  
Corresponding Affymetrix probe sets: 218246_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264198
NCBI entrez gene - 79594     See in Manteia.
OMIM - 612037
RefSeq - XM_011542137
RefSeq - NM_024544
RefSeq Peptide - NP_078820
swissprot - Q969V5
swissprot - A0A024RAA0
Ensembl - ENSG00000090432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mul1bENSDARG00000052527Danio rerio
 MUL1ENSGALG00000042761Gallus gallus
 Mul1ENSMUSG00000041241Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR022170  E3 Ubiquitin ligase, GIDE-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006996 organelle organization IEA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0010637 negative regulation of mitochondrial fusion IDA
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0033235 positive regulation of protein sumoylation IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0050689 negative regulation of defense response to virus by host IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051646 mitochondrion localization IMP
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IDA
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IDA
 biological_processGO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production IMP
 biological_processGO:0090141 positive regulation of mitochondrial fission IDA
 biological_processGO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IMP
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 cellular_componentGO:0043025 neuronal cell body IMP
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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