ENSMUSG00000041241


Mus musculus

Features
Gene ID: ENSMUSG00000041241
  
Biological name :Mul1
  
Synonyms : Mitochondrial ubiquitin ligase activator of NFKB 1 / Mul1 / Q8VCM5
  
Possible biological names infered from orthology : mitochondrial E3 ubiquitin protein ligase 1 / Q969V5
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 138434671
Gene end: 138442265
  
Corresponding Affymetrix probe sets: 10509562 (MoGene1.0st)   1434118_at (Mouse Genome 430 2.0 Array)   1451401_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039604
Ensembl peptide - ENSMUSP00000101439
Ensembl peptide - ENSMUSP00000101441
NCBI entrez gene - 68350     See in Manteia.
MGI - MGI:1915600
RefSeq - NM_026689
RefSeq - XM_006539134
RefSeq Peptide - NP_080965
swissprot - Q8VCM5
Ensembl - ENSMUSG00000041241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mul1bENSDARG00000052527Danio rerio
 MUL1ENSGALG00000042761Gallus gallus
 MUL1ENSG00000090432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR022170  E3 Ubiquitin ligase, GIDE-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0006996 organelle organization IEA
 biological_processGO:0007257 activation of JUN kinase activity ISS
 biological_processGO:0010637 negative regulation of mitochondrial fusion ISO
 biological_processGO:0010821 regulation of mitochondrion organization ISO
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031648 protein destabilization ISO
 biological_processGO:0033235 positive regulation of protein sumoylation ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0045824 negative regulation of innate immune response ISS
 biological_processGO:0050689 negative regulation of defense response to virus by host ISS
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051646 mitochondrion localization ISS
 biological_processGO:0051881 regulation of mitochondrial membrane potential IGI
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISS
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway ISS
 biological_processGO:0071360 cellular response to exogenous dsRNA ISS
 biological_processGO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production ISO
 biological_processGO:0090141 positive regulation of mitochondrial fission ISO
 biological_processGO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
 biological_processGO:1903861 positive regulation of dendrite extension IMP
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IMP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane ISO
 cellular_componentGO:0043025 neuronal cell body ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0004871 obsolete signal transducer activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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