ENSG00000095752


Homo sapiens

Features
Gene ID: ENSG00000095752
  
Biological name :IL11
  
Synonyms : IL11 / interleukin 11 / P20809
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.42
Gene start: 55364389
Gene end: 55370463
  
Corresponding Affymetrix probe sets: 206924_at (Human Genome U133 Plus 2.0 Array)   206926_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467355
Ensembl peptide - ENSP00000468663
Ensembl peptide - ENSP00000264563
Ensembl peptide - ENSP00000465705
NCBI entrez gene - 3589     See in Manteia.
OMIM - 147681
RefSeq - NM_001267718
RefSeq - NM_000641
RefSeq Peptide - NP_000632
RefSeq Peptide - NP_001254647
swissprot - P20809
swissprot - A8K3F7
swissprot - K7ESD5
Ensembl - ENSG00000095752
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il11ENSMUSG00000004371Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR020412  Interleukin-11, mammalian
 IPR020438  Interleukin-11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030183 B cell differentiation NAS
 biological_processGO:0030219 megakaryocyte differentiation NAS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045444 fat cell differentiation NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046888 negative regulation of hormone secretion IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005142 interleukin-11 receptor binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / reaction / complex
 ENSG00000137070 IL11RA / Q14626 / interleukin 11 receptor subunit alpha  / reaction / complex






 

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