ENSG00000099910


Homo sapiens

Features
Gene ID: ENSG00000099910
  
Biological name :KLHL22
  
Synonyms : kelch like family member 22 / KLHL22 / Q53GT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.21
Gene start: 20441519
Gene end: 20495883
  
Corresponding Affymetrix probe sets: 221837_at (Human Genome U133 Plus 2.0 Array)   221838_at (Human Genome U133 Plus 2.0 Array)   221948_s_at (Human Genome U133 Plus 2.0 Array)   222141_at (Human Genome U133 Plus 2.0 Array)   49329_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331682
Ensembl peptide - ENSP00000409092
Ensembl peptide - ENSP00000403999
Ensembl peptide - ENSP00000402746
Ensembl peptide - ENSP00000400095
Ensembl peptide - ENSP00000398616
Ensembl peptide - ENSP00000397882
NCBI entrez gene - 84861     See in Manteia.
RefSeq - XM_017029018
RefSeq - XM_017029020
RefSeq - XM_017029021
RefSeq - XM_017029022
RefSeq - XM_017029023
RefSeq - XM_017029024
RefSeq - XM_017029025
RefSeq - XM_017029019
RefSeq - NM_032775
RefSeq Peptide - NP_116164
swissprot - Q53GT1
swissprot - C9JLE9
swissprot - C9JHG1
swissprot - C9J5F8
swissprot - C9J2T1
swissprot - C9J191
swissprot - C9JRG9
Ensembl - ENSG00000099910
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl22ENSDARG00000088807Danio rerio
 KLHL22ENSGALG00000006422Gallus gallus
 Klhl22ENSMUSG00000022750Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLHL36 / Q8N4N3 / kelch like family member 36ENSG0000013568631
KLHL9 / Q9P2J3 / kelch like family member 9ENSG0000019864231
KLHL13 / Q9P2N7 / kelch like family member 13ENSG0000000309631
KLHL26 / Q53HC5 / kelch like family member 26ENSG0000016748730
KLHL15 / Q96M94 / kelch like family member 15ENSG0000017401027
KLHL32 / Q96NJ5 / kelch like family member 32ENSG0000018623127
KLHL31 / Q9H511 / kelch like family member 31ENSG0000012474327
KLHL14 / Q9P2G3 / kelch like family member 14ENSG0000019770526
KLHL34 / Q8N239 / kelch like family member 34ENSG0000018591526
KLHL7 / Q8IXQ5 / kelch like family member 7ENSG0000012255023
IPP / Q9Y573 / intracisternal A particle-promoted polypeptideENSG0000019742923
Q9Y6Y0 / IVNS1ABP / influenza virus NS1A binding proteinENSG0000011667920
A6NCF5 / KLHL33 / kelch like family member 33ENSG0000018527120
GAN / Q9H2C0 / gigaxoninENSG0000026160918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR030575  Kelch-like protein 22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IMP
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005827 polar microtubule IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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