ENSG00000099985


Homo sapiens

Features
Gene ID: ENSG00000099985
  
Biological name :OSM
  
Synonyms : oncostatin M / OSM / P13725
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.2
Gene start: 30262829
Gene end: 30266840
  
Corresponding Affymetrix probe sets: 214637_at (Human Genome U133 Plus 2.0 Array)   230170_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000215781
Ensembl peptide - ENSP00000384543
Ensembl peptide - ENSP00000383893
NCBI entrez gene - 5008     See in Manteia.
OMIM - 165095
RefSeq - NM_020530
RefSeq - NM_001319108
RefSeq Peptide - NP_001306037
RefSeq Peptide - NP_065391
swissprot - P13725
swissprot - B5MCX1
swissprot - B5MC70
Ensembl - ENSG00000099985
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OsmENSMUSG00000058755Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001581  Leukemia inhibitory factor /oncostatin
 IPR009079  Four-helical cytokine-like, core
 IPR019827  Leukemia inhibitory factor /oncostatin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002675 positive regulation of acute inflammatory response IC
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0038165 oncostatin-M-mediated signaling pathway IDA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046888 negative regulation of hormone secretion IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005147 oncostatin-M receptor binding TAS
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / complex / reaction
 ENSG00000145623 OSMR / Q99650 / oncostatin M receptor  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex






 

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