ENSG00000100106


Homo sapiens

Features
Gene ID: ENSG00000100106
  
Biological name :TRIOBP
  
Synonyms : Q9H2D6 / TRIO and F-actin binding protein / TRIOBP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 37696988
Gene end: 37776556
  
Corresponding Affymetrix probe sets: 1552332_at (Human Genome U133 Plus 2.0 Array)   1552334_at (Human Genome U133 Plus 2.0 Array)   202795_x_at (Human Genome U133 Plus 2.0 Array)   210276_s_at (Human Genome U133 Plus 2.0 Array)   216210_x_at (Human Genome U133 Plus 2.0 Array)   243690_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387881
Ensembl peptide - ENSP00000400680
Ensembl peptide - ENSP00000407542
Ensembl peptide - ENSP00000495322
Ensembl peptide - ENSP00000496394
Ensembl peptide - ENSP00000340312
Ensembl peptide - ENSP00000383913
Ensembl peptide - ENSP00000384312
Ensembl peptide - ENSP00000386026
Ensembl peptide - ENSP00000396946
Ensembl peptide - ENSP00000399006
NCBI entrez gene - 11078     See in Manteia.
OMIM - 609761
RefSeq - NM_007032
RefSeq - NM_138632
RefSeq - NM_001039141
RefSeq Peptide - NP_008963
RefSeq Peptide - NP_001034230
RefSeq Peptide - NP_619538
swissprot - Q9H2D6
swissprot - F6TR96
swissprot - F6WMF4
swissprot - F6WYE2
swissprot - H0Y5J9
swissprot - H0Y5T8
swissprot - H7BXW4
Ensembl - ENSG00000100106
  
Related genetic diseases (OMIM): 609823 - Deafness, autosomal recessive 28, 609823
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 triobpaENSDARG00000075870Danio rerio
 triobpbENSDARG00000006385Danio rerio
 ENSGALG00000045591Gallus gallus
 ENSGALG00000034518Gallus gallus
 Q99KW3ENSMUSG00000033088Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MPRIP / Q6WCQ1 / myosin phosphatase Rho interacting proteinENSG0000013303012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029908  TRIO and F-actin-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0030047 actin modification NAS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0051016 barbed-end actin filament capping NAS
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060088 auditory receptor cell stereocilium organization IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032437 cuticular plate IEA
 cellular_componentGO:0120043 stereocilium shaft IEA
 cellular_componentGO:0120044 stereocilium base IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0017049 GTP-Rho binding NAS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0045159 myosin II binding NAS
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0003593 Early onset 
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 HP:0008625 Severe sensorineural hearing loss 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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